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Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis

Background: In the era of antibiotic resistance, an antibiotic-sparing approach presents an interesting alternative treatment of uncomplicated cystitis in women. Our aim is to perform a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing...

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Autores principales: Cai, Tommaso, Anceschi, Umberto, Tamanini, Irene, Migno, Serena, Rizzo, Michele, Liguori, Giovanni, Garcia-Larrosa, Alejandro, Palmieri, Alessandro, Verze, Paolo, Mirone, Vincenzo, Bjerklund Johansen, Truls E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773311/
https://www.ncbi.nlm.nih.gov/pubmed/35052890
http://dx.doi.org/10.3390/antibiotics11010014
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author Cai, Tommaso
Anceschi, Umberto
Tamanini, Irene
Migno, Serena
Rizzo, Michele
Liguori, Giovanni
Garcia-Larrosa, Alejandro
Palmieri, Alessandro
Verze, Paolo
Mirone, Vincenzo
Bjerklund Johansen, Truls E.
author_facet Cai, Tommaso
Anceschi, Umberto
Tamanini, Irene
Migno, Serena
Rizzo, Michele
Liguori, Giovanni
Garcia-Larrosa, Alejandro
Palmieri, Alessandro
Verze, Paolo
Mirone, Vincenzo
Bjerklund Johansen, Truls E.
author_sort Cai, Tommaso
collection PubMed
description Background: In the era of antibiotic resistance, an antibiotic-sparing approach presents an interesting alternative treatment of uncomplicated cystitis in women. Our aim is to perform a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing xyloglucan, hibiscus and propolis (XHP) in women with uncomplicated cystitis. Methods: Relevant databases were searched using methods recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The primary endpoint was clinical or microbiological success, defined as the complete (cure) and/or non-complete (improvement) resolution of symptoms at the end of treatment, or microbiological resolutions. Results: After screening 21 articles, three studies were included, recruiting a total of 178 patients. All three studies used placebo as comparator. A statistically significant difference was found in terms of clinical or microbiological resolution between the medical device and the comparator (3 RCTs, 178 patients, OR: 0.13; 95% CI: 0.05–0.33; p < 0.0001). No clinically significant adverse effects have been reported. Conclusion: A medical device containing xyloglucan, hibiscus and propolis is superior to comparator regimens in terms of clinical effectiveness in adult women with microbiologically confirmed or clinical suspicion of uncomplicated cystitis and is associated with a high patient compliance.
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spelling pubmed-87733112022-01-21 Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis Cai, Tommaso Anceschi, Umberto Tamanini, Irene Migno, Serena Rizzo, Michele Liguori, Giovanni Garcia-Larrosa, Alejandro Palmieri, Alessandro Verze, Paolo Mirone, Vincenzo Bjerklund Johansen, Truls E. Antibiotics (Basel) Review Background: In the era of antibiotic resistance, an antibiotic-sparing approach presents an interesting alternative treatment of uncomplicated cystitis in women. Our aim is to perform a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing xyloglucan, hibiscus and propolis (XHP) in women with uncomplicated cystitis. Methods: Relevant databases were searched using methods recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The primary endpoint was clinical or microbiological success, defined as the complete (cure) and/or non-complete (improvement) resolution of symptoms at the end of treatment, or microbiological resolutions. Results: After screening 21 articles, three studies were included, recruiting a total of 178 patients. All three studies used placebo as comparator. A statistically significant difference was found in terms of clinical or microbiological resolution between the medical device and the comparator (3 RCTs, 178 patients, OR: 0.13; 95% CI: 0.05–0.33; p < 0.0001). No clinically significant adverse effects have been reported. Conclusion: A medical device containing xyloglucan, hibiscus and propolis is superior to comparator regimens in terms of clinical effectiveness in adult women with microbiologically confirmed or clinical suspicion of uncomplicated cystitis and is associated with a high patient compliance. MDPI 2021-12-23 /pmc/articles/PMC8773311/ /pubmed/35052890 http://dx.doi.org/10.3390/antibiotics11010014 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cai, Tommaso
Anceschi, Umberto
Tamanini, Irene
Migno, Serena
Rizzo, Michele
Liguori, Giovanni
Garcia-Larrosa, Alejandro
Palmieri, Alessandro
Verze, Paolo
Mirone, Vincenzo
Bjerklund Johansen, Truls E.
Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title_full Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title_fullStr Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title_full_unstemmed Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title_short Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis
title_sort xyloglucan, hibiscus and propolis in the management of uncomplicated lower urinary tract infections: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773311/
https://www.ncbi.nlm.nih.gov/pubmed/35052890
http://dx.doi.org/10.3390/antibiotics11010014
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