Cargando…

The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age

Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and J...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Huiling, Hildon, Zoe Jane-Lara, Lye, David Chien Boon, Straughan, Paulin Tay, Chow, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773329/
https://www.ncbi.nlm.nih.gov/pubmed/35052924
http://dx.doi.org/10.3390/antibiotics11010047
_version_ 1784636057717833728
author Guo, Huiling
Hildon, Zoe Jane-Lara
Lye, David Chien Boon
Straughan, Paulin Tay
Chow, Angela
author_facet Guo, Huiling
Hildon, Zoe Jane-Lara
Lye, David Chien Boon
Straughan, Paulin Tay
Chow, Angela
author_sort Guo, Huiling
collection PubMed
description Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and January 2021. Knowledge of antibiotic use and AMR using the World Health Organization’s Multi-Country AMR Survey questionnaire, and antibiotic practices were examined. Multivariable logistic regression was performed to identify factors associated with inappropriate antibiotic use and examine effect measure modifications. Results: After adjusting for potential confounding, poor knowledge of antibiotic use was associated with a 3x increased odds of inappropriate antibiotic use in adults aged ≥50 years (aOR 3.11, 95% CI [2.24–4.32]), 5× increased odds in those aged 35–49 years (aOR 4.88, 95% CI [3.32–7.16]), and 7× increased odds in those aged 21–34 years (aOR 6.58, 95% CI [4.19–10.33]). While there was no statistically significant association in adults aged ≥50 years, poor knowledge of AMR increased the odds of inappropriate antibiotic use by 4 times in adults aged 35–49 years (aOR 3.73, 95% CI [1.53–9.11]) and 5 times in those aged 21–34 years (aOR 4.90, 95% CI [1.84–13.02]). Conclusions: Targeted educational interventions for specific age groups are needed in conjunction with empowering the public with knowledge of antibiotic use and AMR.
format Online
Article
Text
id pubmed-8773329
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87733292022-01-21 The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age Guo, Huiling Hildon, Zoe Jane-Lara Lye, David Chien Boon Straughan, Paulin Tay Chow, Angela Antibiotics (Basel) Article Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and January 2021. Knowledge of antibiotic use and AMR using the World Health Organization’s Multi-Country AMR Survey questionnaire, and antibiotic practices were examined. Multivariable logistic regression was performed to identify factors associated with inappropriate antibiotic use and examine effect measure modifications. Results: After adjusting for potential confounding, poor knowledge of antibiotic use was associated with a 3x increased odds of inappropriate antibiotic use in adults aged ≥50 years (aOR 3.11, 95% CI [2.24–4.32]), 5× increased odds in those aged 35–49 years (aOR 4.88, 95% CI [3.32–7.16]), and 7× increased odds in those aged 21–34 years (aOR 6.58, 95% CI [4.19–10.33]). While there was no statistically significant association in adults aged ≥50 years, poor knowledge of AMR increased the odds of inappropriate antibiotic use by 4 times in adults aged 35–49 years (aOR 3.73, 95% CI [1.53–9.11]) and 5 times in those aged 21–34 years (aOR 4.90, 95% CI [1.84–13.02]). Conclusions: Targeted educational interventions for specific age groups are needed in conjunction with empowering the public with knowledge of antibiotic use and AMR. MDPI 2021-12-30 /pmc/articles/PMC8773329/ /pubmed/35052924 http://dx.doi.org/10.3390/antibiotics11010047 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Huiling
Hildon, Zoe Jane-Lara
Lye, David Chien Boon
Straughan, Paulin Tay
Chow, Angela
The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title_full The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title_fullStr The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title_full_unstemmed The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title_short The Associations between Poor Antibiotic and Antimicrobial Resistance Knowledge and Inappropriate Antibiotic Use in the General Population Are Modified by Age
title_sort associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773329/
https://www.ncbi.nlm.nih.gov/pubmed/35052924
http://dx.doi.org/10.3390/antibiotics11010047
work_keys_str_mv AT guohuiling theassociationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT hildonzoejanelara theassociationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT lyedavidchienboon theassociationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT straughanpaulintay theassociationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT chowangela theassociationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT guohuiling associationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT hildonzoejanelara associationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT lyedavidchienboon associationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT straughanpaulintay associationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage
AT chowangela associationsbetweenpoorantibioticandantimicrobialresistanceknowledgeandinappropriateantibioticuseinthegeneralpopulationaremodifiedbyage