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Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies

Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with...

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Autores principales: Gil-Melgosa, Lara, Grasa, Jorge, Urbiola, Ainhoa, Llombart, Rafael, Susaeta Ruiz, Miguel, Montiel, Verónica, Ederra, Cristina, Calvo, Begoña, Ariz, Mikel, Ripalda-Cemborain, Purificación, Prosper, Felipe, Ortiz-de-Solórzano, Carlos, Pons-Villanueva, Juan, Pérez Ruiz, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773411/
https://www.ncbi.nlm.nih.gov/pubmed/35052699
http://dx.doi.org/10.3390/biomedicines10010019
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author Gil-Melgosa, Lara
Grasa, Jorge
Urbiola, Ainhoa
Llombart, Rafael
Susaeta Ruiz, Miguel
Montiel, Verónica
Ederra, Cristina
Calvo, Begoña
Ariz, Mikel
Ripalda-Cemborain, Purificación
Prosper, Felipe
Ortiz-de-Solórzano, Carlos
Pons-Villanueva, Juan
Pérez Ruiz, Ana
author_facet Gil-Melgosa, Lara
Grasa, Jorge
Urbiola, Ainhoa
Llombart, Rafael
Susaeta Ruiz, Miguel
Montiel, Verónica
Ederra, Cristina
Calvo, Begoña
Ariz, Mikel
Ripalda-Cemborain, Purificación
Prosper, Felipe
Ortiz-de-Solórzano, Carlos
Pons-Villanueva, Juan
Pérez Ruiz, Ana
author_sort Gil-Melgosa, Lara
collection PubMed
description Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with muscle fatty degeneration contributing to function loss. Despite clinical outcomes, pre-clinical research has mainly focused on tendon structural repair, with a lack of knowledge regarding injury progression from tendon to muscle and its consequences on muscle degenerative/regenerative processes and function. Here, we characterize the morphological changes in the tendon, the myotendinous junction and muscle belly in a mouse model of Achilles tendon complete rupture, finding cellular and fatty infiltration, fibrotic tissue accumulation, muscle stem cell decline and collagen fiber disorganization. We use novel imaging technologies to accurately relate structural alterations in tendon fibers to pathological changes, which further explain the loss of muscle mechanical function after tendon rupture. The treatment of tendon injuries remains a challenge for orthopedics. Thus, the main goal of this study is to bridge the gap between clinicians’ knowledge and research to address the underlying pathophysiology of ruptured Achilles tendon and its consequences in the gastrocnemius. Such studies are necessary if current practices in regenerative medicine for Achilles tendon ruptures are to be improved.
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spelling pubmed-87734112022-01-21 Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies Gil-Melgosa, Lara Grasa, Jorge Urbiola, Ainhoa Llombart, Rafael Susaeta Ruiz, Miguel Montiel, Verónica Ederra, Cristina Calvo, Begoña Ariz, Mikel Ripalda-Cemborain, Purificación Prosper, Felipe Ortiz-de-Solórzano, Carlos Pons-Villanueva, Juan Pérez Ruiz, Ana Biomedicines Communication Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with muscle fatty degeneration contributing to function loss. Despite clinical outcomes, pre-clinical research has mainly focused on tendon structural repair, with a lack of knowledge regarding injury progression from tendon to muscle and its consequences on muscle degenerative/regenerative processes and function. Here, we characterize the morphological changes in the tendon, the myotendinous junction and muscle belly in a mouse model of Achilles tendon complete rupture, finding cellular and fatty infiltration, fibrotic tissue accumulation, muscle stem cell decline and collagen fiber disorganization. We use novel imaging technologies to accurately relate structural alterations in tendon fibers to pathological changes, which further explain the loss of muscle mechanical function after tendon rupture. The treatment of tendon injuries remains a challenge for orthopedics. Thus, the main goal of this study is to bridge the gap between clinicians’ knowledge and research to address the underlying pathophysiology of ruptured Achilles tendon and its consequences in the gastrocnemius. Such studies are necessary if current practices in regenerative medicine for Achilles tendon ruptures are to be improved. MDPI 2021-12-23 /pmc/articles/PMC8773411/ /pubmed/35052699 http://dx.doi.org/10.3390/biomedicines10010019 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gil-Melgosa, Lara
Grasa, Jorge
Urbiola, Ainhoa
Llombart, Rafael
Susaeta Ruiz, Miguel
Montiel, Verónica
Ederra, Cristina
Calvo, Begoña
Ariz, Mikel
Ripalda-Cemborain, Purificación
Prosper, Felipe
Ortiz-de-Solórzano, Carlos
Pons-Villanueva, Juan
Pérez Ruiz, Ana
Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title_full Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title_fullStr Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title_full_unstemmed Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title_short Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies
title_sort muscular and tendon degeneration after achilles rupture: new insights into future repair strategies
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773411/
https://www.ncbi.nlm.nih.gov/pubmed/35052699
http://dx.doi.org/10.3390/biomedicines10010019
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