Cargando…
Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease
Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773471/ https://www.ncbi.nlm.nih.gov/pubmed/35052869 http://dx.doi.org/10.3390/biomedicines10010190 |
_version_ | 1784636094748295168 |
---|---|
author | Lee, Yu-Ran Bae, Eun Young Kil, Hong Ryang Jeon, Byeong-Hwa Kim, Geena |
author_facet | Lee, Yu-Ran Bae, Eun Young Kil, Hong Ryang Jeon, Byeong-Hwa Kim, Geena |
author_sort | Lee, Yu-Ran |
collection | PubMed |
description | Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD. Three groups, including 32 patients with KD (KD group), 33 patients with fever (Fever group), and 19 healthy individuals (Healthy group), were prospectively analyzed. APE1/Ref-1 levels were measured, and the clinical characteristics of KD were evaluated. The mean age of all patients was 2.7 ± 1.8 years, but the Healthy group participants were older than the other participants. Fever duration was longer in the KD group than in the fever group. APE1/Ref-1 levels were significantly higher in the KD group (p = 0.004) than in the other two groups, but there was no difference between the healthy and fever groups. APE1/Ref-1 levels did not differ according to fever duration or coronary arterial lesion but were higher in refractory KD cases than in non-refractory cases. APE1/Ref-1 levels were significantly higher during the acute phase of KD. We propose that APE1/Ref-1 could be a beneficial biological marker for the diagnosis and prognosis of KD, especially in refractory KD. |
format | Online Article Text |
id | pubmed-8773471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87734712022-01-21 Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease Lee, Yu-Ran Bae, Eun Young Kil, Hong Ryang Jeon, Byeong-Hwa Kim, Geena Biomedicines Article Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD. Three groups, including 32 patients with KD (KD group), 33 patients with fever (Fever group), and 19 healthy individuals (Healthy group), were prospectively analyzed. APE1/Ref-1 levels were measured, and the clinical characteristics of KD were evaluated. The mean age of all patients was 2.7 ± 1.8 years, but the Healthy group participants were older than the other participants. Fever duration was longer in the KD group than in the fever group. APE1/Ref-1 levels were significantly higher in the KD group (p = 0.004) than in the other two groups, but there was no difference between the healthy and fever groups. APE1/Ref-1 levels did not differ according to fever duration or coronary arterial lesion but were higher in refractory KD cases than in non-refractory cases. APE1/Ref-1 levels were significantly higher during the acute phase of KD. We propose that APE1/Ref-1 could be a beneficial biological marker for the diagnosis and prognosis of KD, especially in refractory KD. MDPI 2022-01-17 /pmc/articles/PMC8773471/ /pubmed/35052869 http://dx.doi.org/10.3390/biomedicines10010190 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Yu-Ran Bae, Eun Young Kil, Hong Ryang Jeon, Byeong-Hwa Kim, Geena Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title_full | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title_fullStr | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title_full_unstemmed | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title_short | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
title_sort | elevated plasma apurinic/apyrimidinic endonuclease 1/redox effector factor-1 levels in refractory kawasaki disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773471/ https://www.ncbi.nlm.nih.gov/pubmed/35052869 http://dx.doi.org/10.3390/biomedicines10010190 |
work_keys_str_mv | AT leeyuran elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT baeeunyoung elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT kilhongryang elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT jeonbyeonghwa elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT kimgeena elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease |