Oxysterols in the Immune Response to Bacterial and Viral Infections

Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections. This review summarizes our current knowledge of selected oxystero...

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Detalles Bibliográficos
Autores principales: Foo, Cheng Xiang, Bartlett, Stacey, Ronacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773517/
https://www.ncbi.nlm.nih.gov/pubmed/35053318
http://dx.doi.org/10.3390/cells11020201
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author Foo, Cheng Xiang
Bartlett, Stacey
Ronacher, Katharina
author_facet Foo, Cheng Xiang
Bartlett, Stacey
Ronacher, Katharina
author_sort Foo, Cheng Xiang
collection PubMed
description Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections. This review summarizes our current knowledge of selected oxysterols and their receptors in the control of intracellular bacterial growth as well as viral entry into the host cell and viral replication. Lastly, we briefly discuss the potential of oxysterols and their receptors as drug targets for infectious and inflammatory diseases.
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spelling pubmed-87735172022-01-21 Oxysterols in the Immune Response to Bacterial and Viral Infections Foo, Cheng Xiang Bartlett, Stacey Ronacher, Katharina Cells Review Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections. This review summarizes our current knowledge of selected oxysterols and their receptors in the control of intracellular bacterial growth as well as viral entry into the host cell and viral replication. Lastly, we briefly discuss the potential of oxysterols and their receptors as drug targets for infectious and inflammatory diseases. MDPI 2022-01-07 /pmc/articles/PMC8773517/ /pubmed/35053318 http://dx.doi.org/10.3390/cells11020201 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Foo, Cheng Xiang
Bartlett, Stacey
Ronacher, Katharina
Oxysterols in the Immune Response to Bacterial and Viral Infections
title Oxysterols in the Immune Response to Bacterial and Viral Infections
title_full Oxysterols in the Immune Response to Bacterial and Viral Infections
title_fullStr Oxysterols in the Immune Response to Bacterial and Viral Infections
title_full_unstemmed Oxysterols in the Immune Response to Bacterial and Viral Infections
title_short Oxysterols in the Immune Response to Bacterial and Viral Infections
title_sort oxysterols in the immune response to bacterial and viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773517/
https://www.ncbi.nlm.nih.gov/pubmed/35053318
http://dx.doi.org/10.3390/cells11020201
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AT ronacherkatharina oxysterolsintheimmuneresponsetobacterialandviralinfections

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