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Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study

Background: The COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset o...

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Autores principales: Mekkawy, Doaa A., Hamdy, Sherif, Abdel-Naseer, Maged, Shehata, Hatem S., Halfawy, Ahmed Al, Shalaby, Nevin M., Shehata, Ghaydaa A., Ali, Anwar M., Elmazny, Alaa, Ahmed, Sandra M., Ismail, Jumana H., Ibraheim, Aml, Abdel-Hamid, Hoda M., Magdy, Rehab, Kabara Ayoub, Younan, Taha, Ahmed E., Merghany, Nahla, Soliman, Nourhan M., Elshebawy, Haidy, Abdelal, Samar E. S., El-Ghoneimy, Lobna, Al-Athwari, Aussan, Kishk, Nirmeen A., Nada, Mona A. F., Farghaly, Marwa, Hassan, Amr, Hegazy, Mohamed I., Abdelalim, Ahmed, Mourad, Husam S., Hassouna, Amira, Othman, Alshimaa S., Wijeratne, Tissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773531/
https://www.ncbi.nlm.nih.gov/pubmed/35053817
http://dx.doi.org/10.3390/brainsci12010074
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author Mekkawy, Doaa A.
Hamdy, Sherif
Abdel-Naseer, Maged
Shehata, Hatem S.
Halfawy, Ahmed Al
Shalaby, Nevin M.
Shehata, Ghaydaa A.
Ali, Anwar M.
Elmazny, Alaa
Ahmed, Sandra M.
Ismail, Jumana H.
Ibraheim, Aml
Abdel-Hamid, Hoda M.
Magdy, Rehab
Kabara Ayoub, Younan
Taha, Ahmed E.
Merghany, Nahla
Soliman, Nourhan M.
Elshebawy, Haidy
Abdelal, Samar E. S.
El-Ghoneimy, Lobna
Al-Athwari, Aussan
Kishk, Nirmeen A.
Nada, Mona A. F.
Farghaly, Marwa
Hassan, Amr
Hegazy, Mohamed I.
Abdelalim, Ahmed
Mourad, Husam S.
Hassouna, Amira
Othman, Alshimaa S.
Wijeratne, Tissa
author_facet Mekkawy, Doaa A.
Hamdy, Sherif
Abdel-Naseer, Maged
Shehata, Hatem S.
Halfawy, Ahmed Al
Shalaby, Nevin M.
Shehata, Ghaydaa A.
Ali, Anwar M.
Elmazny, Alaa
Ahmed, Sandra M.
Ismail, Jumana H.
Ibraheim, Aml
Abdel-Hamid, Hoda M.
Magdy, Rehab
Kabara Ayoub, Younan
Taha, Ahmed E.
Merghany, Nahla
Soliman, Nourhan M.
Elshebawy, Haidy
Abdelal, Samar E. S.
El-Ghoneimy, Lobna
Al-Athwari, Aussan
Kishk, Nirmeen A.
Nada, Mona A. F.
Farghaly, Marwa
Hassan, Amr
Hegazy, Mohamed I.
Abdelalim, Ahmed
Mourad, Husam S.
Hassouna, Amira
Othman, Alshimaa S.
Wijeratne, Tissa
author_sort Mekkawy, Doaa A.
collection PubMed
description Background: The COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset of infection are worth exploring. The aim of the current body of work was to determine the frequency, pattern, and temporal profile of neurological manifestations in a cohort of Egyptian patients with confirmed COVID-19 infection. Methods: This was a prospective study conducted on 582 hospitalized COVID-19 patients within the first two weeks of the diagnosis of COVID-19 to detect any specific or non-specific neurological events. Results: The patients’ mean (SD) age was 46.74 (17.26) years, and 340 (58.42%) patients were females. The most commonly encountered COVID-19 symptoms were fever (90.72%), cough (82.99%), and fatigue (76.98%). Neurological events (NE) detected in 283 patients (48.63%) and were significantly associated with a severe COVID-19 at the onset (OR: 3.13; 95% CI: 2.18–4.51; p < 0.0001) and with a higher mortality (OR: 2.56; 95% CI: 1.48–5.46; p = 0.019). The most frequently reported NEs were headaches (n = 167) and myalgias (n = 126). Neurological syndromes included stroke (n = 14), encephalitis (n = 12), encephalopathy (n = 11), transverse myelitis (n = 6) and Guillain-Barré syndrome (n = 4). Conclusions: Neurological involvement is common (48.63%) in COVID-19 patients within the first two weeks of the illness. This includes neurological symptoms such as anosmia, headaches, as well as a constellation of neurological syndromes such as stroke, encephalitis, transverse myelitis, and Guillain-Barré syndrome. Severity of acute COVID-19 illness and older age are the main risk factors.
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spelling pubmed-87735312022-01-21 Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study Mekkawy, Doaa A. Hamdy, Sherif Abdel-Naseer, Maged Shehata, Hatem S. Halfawy, Ahmed Al Shalaby, Nevin M. Shehata, Ghaydaa A. Ali, Anwar M. Elmazny, Alaa Ahmed, Sandra M. Ismail, Jumana H. Ibraheim, Aml Abdel-Hamid, Hoda M. Magdy, Rehab Kabara Ayoub, Younan Taha, Ahmed E. Merghany, Nahla Soliman, Nourhan M. Elshebawy, Haidy Abdelal, Samar E. S. El-Ghoneimy, Lobna Al-Athwari, Aussan Kishk, Nirmeen A. Nada, Mona A. F. Farghaly, Marwa Hassan, Amr Hegazy, Mohamed I. Abdelalim, Ahmed Mourad, Husam S. Hassouna, Amira Othman, Alshimaa S. Wijeratne, Tissa Brain Sci Article Background: The COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset of infection are worth exploring. The aim of the current body of work was to determine the frequency, pattern, and temporal profile of neurological manifestations in a cohort of Egyptian patients with confirmed COVID-19 infection. Methods: This was a prospective study conducted on 582 hospitalized COVID-19 patients within the first two weeks of the diagnosis of COVID-19 to detect any specific or non-specific neurological events. Results: The patients’ mean (SD) age was 46.74 (17.26) years, and 340 (58.42%) patients were females. The most commonly encountered COVID-19 symptoms were fever (90.72%), cough (82.99%), and fatigue (76.98%). Neurological events (NE) detected in 283 patients (48.63%) and were significantly associated with a severe COVID-19 at the onset (OR: 3.13; 95% CI: 2.18–4.51; p < 0.0001) and with a higher mortality (OR: 2.56; 95% CI: 1.48–5.46; p = 0.019). The most frequently reported NEs were headaches (n = 167) and myalgias (n = 126). Neurological syndromes included stroke (n = 14), encephalitis (n = 12), encephalopathy (n = 11), transverse myelitis (n = 6) and Guillain-Barré syndrome (n = 4). Conclusions: Neurological involvement is common (48.63%) in COVID-19 patients within the first two weeks of the illness. This includes neurological symptoms such as anosmia, headaches, as well as a constellation of neurological syndromes such as stroke, encephalitis, transverse myelitis, and Guillain-Barré syndrome. Severity of acute COVID-19 illness and older age are the main risk factors. MDPI 2022-01-01 /pmc/articles/PMC8773531/ /pubmed/35053817 http://dx.doi.org/10.3390/brainsci12010074 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mekkawy, Doaa A.
Hamdy, Sherif
Abdel-Naseer, Maged
Shehata, Hatem S.
Halfawy, Ahmed Al
Shalaby, Nevin M.
Shehata, Ghaydaa A.
Ali, Anwar M.
Elmazny, Alaa
Ahmed, Sandra M.
Ismail, Jumana H.
Ibraheim, Aml
Abdel-Hamid, Hoda M.
Magdy, Rehab
Kabara Ayoub, Younan
Taha, Ahmed E.
Merghany, Nahla
Soliman, Nourhan M.
Elshebawy, Haidy
Abdelal, Samar E. S.
El-Ghoneimy, Lobna
Al-Athwari, Aussan
Kishk, Nirmeen A.
Nada, Mona A. F.
Farghaly, Marwa
Hassan, Amr
Hegazy, Mohamed I.
Abdelalim, Ahmed
Mourad, Husam S.
Hassouna, Amira
Othman, Alshimaa S.
Wijeratne, Tissa
Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title_full Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title_fullStr Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title_full_unstemmed Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title_short Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
title_sort neurological manifestations in a cohort of egyptian patients with covid-19: a prospective, multicenter, observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773531/
https://www.ncbi.nlm.nih.gov/pubmed/35053817
http://dx.doi.org/10.3390/brainsci12010074
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