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Sodium Binding Stabilizes the Outward-Open State of SERT by Limiting Bundle Domain Motions
The human serotonin transporter (hSERT) removes the neurotransmitter serotonin from the synaptic cleft by reuptake into the presynaptic nerve terminal. A number of neurologic diseases are associated with dysfunction of the hSERT, and several medications for their treatment are hSERT blockers, includ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773566/ https://www.ncbi.nlm.nih.gov/pubmed/35053371 http://dx.doi.org/10.3390/cells11020255 |