A Novel Plant-Derived Choline Transporter-like Protein 1 Inhibitor, Amb544925, Induces Apoptotic Cell Death via the Ceramide/Survivin Pathway in Tongue Squamous Cell Carcinoma

SIMPLE SUMMARY: In many cancer cells, the choline uptake mechanism via the choline transporter-like protein 1 (CTL1) is involved in cell proliferation, and inhibiting its function is known to induce cell death by apoptosis. Therefore, CTL1 is attracting attention as a target molecule for cancer ther...

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Detalles Bibliográficos
Autores principales: Shibata, Kaoru, Nishijima, Nozomi, Hirai, Kaho, Watanabe, Saiichiro, Yamanaka, Tsuyoshi, Chikazu, Daichi, Inazu, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773621/
https://www.ncbi.nlm.nih.gov/pubmed/35053491
http://dx.doi.org/10.3390/cancers14020329

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