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Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart
During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular tissue. In response to injury, there is an increase...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773626/ https://www.ncbi.nlm.nih.gov/pubmed/35053159 http://dx.doi.org/10.3390/biom12010011 |
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author | Corker, Alexa Neff, Lily S. Broughton, Philip Bradshaw, Amy D. DeLeon-Pennell, Kristine Y. |
author_facet | Corker, Alexa Neff, Lily S. Broughton, Philip Bradshaw, Amy D. DeLeon-Pennell, Kristine Y. |
author_sort | Corker, Alexa |
collection | PubMed |
description | During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular tissue. In response to injury, there is an increase in inflammation within the heart due to the influx of immune cells. Some of the most common immune cells recruited to the heart are macrophages, dendritic cells, neutrophils, and T-cells. In this review, we will discuss what is known about cardiac immune cell heterogeneity during homeostasis, how these cell populations change in response to a pathology such as myocardial infarction or pressure overload, and what stimuli are regulating these processes. In addition, we will summarize technologies used to evaluate cell heterogeneity in models of cardiovascular disease. |
format | Online Article Text |
id | pubmed-8773626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87736262022-01-21 Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart Corker, Alexa Neff, Lily S. Broughton, Philip Bradshaw, Amy D. DeLeon-Pennell, Kristine Y. Biomolecules Review During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular tissue. In response to injury, there is an increase in inflammation within the heart due to the influx of immune cells. Some of the most common immune cells recruited to the heart are macrophages, dendritic cells, neutrophils, and T-cells. In this review, we will discuss what is known about cardiac immune cell heterogeneity during homeostasis, how these cell populations change in response to a pathology such as myocardial infarction or pressure overload, and what stimuli are regulating these processes. In addition, we will summarize technologies used to evaluate cell heterogeneity in models of cardiovascular disease. MDPI 2021-12-22 /pmc/articles/PMC8773626/ /pubmed/35053159 http://dx.doi.org/10.3390/biom12010011 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Corker, Alexa Neff, Lily S. Broughton, Philip Bradshaw, Amy D. DeLeon-Pennell, Kristine Y. Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title | Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title_full | Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title_fullStr | Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title_full_unstemmed | Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title_short | Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart |
title_sort | organized chaos: deciphering immune cell heterogeneity’s role in inflammation in the heart |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773626/ https://www.ncbi.nlm.nih.gov/pubmed/35053159 http://dx.doi.org/10.3390/biom12010011 |
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