CDK5RAP3, a New BRCA2 Partner That Regulates DNA Repair, Is Associated with Breast Cancer Survival

SIMPLE SUMMARY: BRCA2 is an essential gene for DNA repair by homologous recombination and is often mutated in families at risk of breast and ovarian cancer. In this study we identified CDK5RAP3 tumor suppressor as a new BRCA2-interacting protein. CDK5RAP3 negatively regulates DNA repair of double-st...

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Detalles Bibliográficos
Autores principales: Minguillón, Jordi, Ramírez, María José, Rovirosa, Llorenç, Bustamante-Madrid, Pilar, Camps-Fajol, Cristina, Ruiz de Garibay, Gorka, Shimelis, Hermela, Montanuy, Helena, Pujol, Roser, Hernandez, Gonzalo, Bogliolo, Massimo, Castillo, Pau, Soucy, Penny, Martrat, Griselda, Gómez, Antonio, Cuadras, Daniel, García, María J., Gayarre, Javier, Lázaro, Conxi, Benítez, Javier, Couch, Fergus J., Pujana, Miquel Angel, Surrallés, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773632/
https://www.ncbi.nlm.nih.gov/pubmed/35053516
http://dx.doi.org/10.3390/cancers14020353

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