Melittin-Based Nano-Delivery Systems for Cancer Therapy

Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its se...

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Detalles Bibliográficos
Autores principales: Wang, Anqi, Zheng, Yuan, Zhu, Wanxin, Yang, Liuxin, Yang, Yang, Peng, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773652/
https://www.ncbi.nlm.nih.gov/pubmed/35053266
http://dx.doi.org/10.3390/biom12010118
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author Wang, Anqi
Zheng, Yuan
Zhu, Wanxin
Yang, Liuxin
Yang, Yang
Peng, Jinliang
author_facet Wang, Anqi
Zheng, Yuan
Zhu, Wanxin
Yang, Liuxin
Yang, Yang
Peng, Jinliang
author_sort Wang, Anqi
collection PubMed
description Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL’s nano-delivery systems and MEL-modified nano drug carriers for cancer therapy.
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spelling pubmed-87736522022-01-21 Melittin-Based Nano-Delivery Systems for Cancer Therapy Wang, Anqi Zheng, Yuan Zhu, Wanxin Yang, Liuxin Yang, Yang Peng, Jinliang Biomolecules Review Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL’s nano-delivery systems and MEL-modified nano drug carriers for cancer therapy. MDPI 2022-01-12 /pmc/articles/PMC8773652/ /pubmed/35053266 http://dx.doi.org/10.3390/biom12010118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Anqi
Zheng, Yuan
Zhu, Wanxin
Yang, Liuxin
Yang, Yang
Peng, Jinliang
Melittin-Based Nano-Delivery Systems for Cancer Therapy
title Melittin-Based Nano-Delivery Systems for Cancer Therapy
title_full Melittin-Based Nano-Delivery Systems for Cancer Therapy
title_fullStr Melittin-Based Nano-Delivery Systems for Cancer Therapy
title_full_unstemmed Melittin-Based Nano-Delivery Systems for Cancer Therapy
title_short Melittin-Based Nano-Delivery Systems for Cancer Therapy
title_sort melittin-based nano-delivery systems for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773652/
https://www.ncbi.nlm.nih.gov/pubmed/35053266
http://dx.doi.org/10.3390/biom12010118
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