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Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition
Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances in signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic mus...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773710/ https://www.ncbi.nlm.nih.gov/pubmed/35053836 http://dx.doi.org/10.3390/brainsci12010093 |
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author | San-Martin, Rodrigo Zimiani, Maria Inês de Ávila, Milton Augusto Vendramini Shuhama, Rosana Del-Ben, Cristina Marta Menezes, Paulo Rossi Fraga, Francisco José Salum, Cristiane |
author_facet | San-Martin, Rodrigo Zimiani, Maria Inês de Ávila, Milton Augusto Vendramini Shuhama, Rosana Del-Ben, Cristina Marta Menezes, Paulo Rossi Fraga, Francisco José Salum, Cristiane |
author_sort | San-Martin, Rodrigo |
collection | PubMed |
description | Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances in signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic muscular PPI). Simultaneous measurements of muscular (eye-blink) and neural gating phenomena during PPI test may help to better understand sensorial processing dysfunctions in psychosis. In this study, we aimed to assess simultaneously muscular and neural PPI in early bipolar disorder and schizophrenia patients. Method: Participants were recruited from a population-based case-control study of first episode psychosis. PPI was measured using electromyography (EMG) and EEG in pulse alone and prepulse + pulse with intervals of 30, 60, and 120 ms in early bipolar disorder (n = 18) and schizophrenia (n = 11) patients. As control group, 15 socio-economically matched healthy subjects were recruited. All subjects were evaluated with Rating Scale, Hamilton Rating Scale for Depression, and Young Mania Rating Scale questionnaires at recruitment and just before PPI test. Wilcoxon ranked sum tests were used to compare PPI test results between groups. Results: In comparison to healthy participants, neural PPI was significantly reduced in PPI 30 and PPI60 among bipolar and schizophrenia patients, while muscular PPI was reduced in PPI60 and PPI120 intervals only among patients with schizophrenia. Conclusion: The combination of muscular and neural PPI evaluations suggested distinct impairment patterns among schizophrenia and bipolar disorder patients. Simultaneous recording may contribute with novel information in sensory gating investigations. |
format | Online Article Text |
id | pubmed-8773710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87737102022-01-21 Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition San-Martin, Rodrigo Zimiani, Maria Inês de Ávila, Milton Augusto Vendramini Shuhama, Rosana Del-Ben, Cristina Marta Menezes, Paulo Rossi Fraga, Francisco José Salum, Cristiane Brain Sci Article Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances in signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic muscular PPI). Simultaneous measurements of muscular (eye-blink) and neural gating phenomena during PPI test may help to better understand sensorial processing dysfunctions in psychosis. In this study, we aimed to assess simultaneously muscular and neural PPI in early bipolar disorder and schizophrenia patients. Method: Participants were recruited from a population-based case-control study of first episode psychosis. PPI was measured using electromyography (EMG) and EEG in pulse alone and prepulse + pulse with intervals of 30, 60, and 120 ms in early bipolar disorder (n = 18) and schizophrenia (n = 11) patients. As control group, 15 socio-economically matched healthy subjects were recruited. All subjects were evaluated with Rating Scale, Hamilton Rating Scale for Depression, and Young Mania Rating Scale questionnaires at recruitment and just before PPI test. Wilcoxon ranked sum tests were used to compare PPI test results between groups. Results: In comparison to healthy participants, neural PPI was significantly reduced in PPI 30 and PPI60 among bipolar and schizophrenia patients, while muscular PPI was reduced in PPI60 and PPI120 intervals only among patients with schizophrenia. Conclusion: The combination of muscular and neural PPI evaluations suggested distinct impairment patterns among schizophrenia and bipolar disorder patients. Simultaneous recording may contribute with novel information in sensory gating investigations. MDPI 2022-01-11 /pmc/articles/PMC8773710/ /pubmed/35053836 http://dx.doi.org/10.3390/brainsci12010093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article San-Martin, Rodrigo Zimiani, Maria Inês de Ávila, Milton Augusto Vendramini Shuhama, Rosana Del-Ben, Cristina Marta Menezes, Paulo Rossi Fraga, Francisco José Salum, Cristiane Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title | Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title_full | Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title_fullStr | Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title_full_unstemmed | Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title_short | Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition |
title_sort | early schizophrenia and bipolar disorder patients display reduced neural prepulse inhibition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773710/ https://www.ncbi.nlm.nih.gov/pubmed/35053836 http://dx.doi.org/10.3390/brainsci12010093 |
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