Cargando…

Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review

Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments,...

Descripción completa

Detalles Bibliográficos
Autores principales: Malik, Shazia, Alnaji, Omar, Malik, Mahnoor, Gambale, Teresa, Rathbone, Michel Piers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773760/
https://www.ncbi.nlm.nih.gov/pubmed/35053845
http://dx.doi.org/10.3390/brainsci12010102
_version_ 1784636175802171392
author Malik, Shazia
Alnaji, Omar
Malik, Mahnoor
Gambale, Teresa
Rathbone, Michel Piers
author_facet Malik, Shazia
Alnaji, Omar
Malik, Mahnoor
Gambale, Teresa
Rathbone, Michel Piers
author_sort Malik, Shazia
collection PubMed
description Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments, particularly depression, anxiety, and post-traumatic stress disorder (PTSD), are commonly associated with poor recovery following mTBI. These emotional impairments also have a significant neuroinflammatory component. We hypothesized that the inflammatory cytokines seen in mTBI patients with emotional symptoms would coincide with those commonly seen in patients with emotional symptoms without mTBI. A systematic review was conducted to identify the most common neuroinflammatory cytokines in the mTBI population with psychological symptoms (depression, anxiety, PTSD). The electronic databases EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and PSYCINFO were searched from data inception to 31 August 2021. A systematic screening approach was employed from screening to data analysis. A total of 994 articles were screened, 108 were selected for full article review, and 8 were selected for data analysis. The included studies consisted of 875 patients of which 81.3% were male. The mean sample size of patients with at least one mTBI was 73.8 ± 70.3 (range, 9–213), with a mean age of 33.9 ± 4.8 years. The most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population were IL-6, TNFα, IL-10, and CRP.
format Online
Article
Text
id pubmed-8773760
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87737602022-01-21 Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review Malik, Shazia Alnaji, Omar Malik, Mahnoor Gambale, Teresa Rathbone, Michel Piers Brain Sci Systematic Review Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments, particularly depression, anxiety, and post-traumatic stress disorder (PTSD), are commonly associated with poor recovery following mTBI. These emotional impairments also have a significant neuroinflammatory component. We hypothesized that the inflammatory cytokines seen in mTBI patients with emotional symptoms would coincide with those commonly seen in patients with emotional symptoms without mTBI. A systematic review was conducted to identify the most common neuroinflammatory cytokines in the mTBI population with psychological symptoms (depression, anxiety, PTSD). The electronic databases EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and PSYCINFO were searched from data inception to 31 August 2021. A systematic screening approach was employed from screening to data analysis. A total of 994 articles were screened, 108 were selected for full article review, and 8 were selected for data analysis. The included studies consisted of 875 patients of which 81.3% were male. The mean sample size of patients with at least one mTBI was 73.8 ± 70.3 (range, 9–213), with a mean age of 33.9 ± 4.8 years. The most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population were IL-6, TNFα, IL-10, and CRP. MDPI 2022-01-12 /pmc/articles/PMC8773760/ /pubmed/35053845 http://dx.doi.org/10.3390/brainsci12010102 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Malik, Shazia
Alnaji, Omar
Malik, Mahnoor
Gambale, Teresa
Rathbone, Michel Piers
Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title_full Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title_fullStr Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title_full_unstemmed Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title_short Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
title_sort correlation between mild traumatic brain injury-induced inflammatory cytokines and emotional symptom traits: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773760/
https://www.ncbi.nlm.nih.gov/pubmed/35053845
http://dx.doi.org/10.3390/brainsci12010102
work_keys_str_mv AT malikshazia correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview
AT alnajiomar correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview
AT malikmahnoor correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview
AT gambaleteresa correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview
AT rathbonemichelpiers correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview