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Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis
Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that is activated by a variety of endogenous metabolites or xenobiotics. Its downstream target genes are involved in metabolism, inflammation and processes closely related to cancer. However, the stability regulation of PXR pr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773821/ https://www.ncbi.nlm.nih.gov/pubmed/35053380 http://dx.doi.org/10.3390/cells11020264 |