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Optical Hydrogel Detector for pH Measurements

Measuring pH has become a major key for determining health conditions, and food safety. The traditional pH assessment approaches are costly and offer low sensitivity. Here, a novel pH sensor based on a pH-responsive hydrogel has been developed. A Fresnel lens pattern was replicated on the surface of...

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Autores principales: Alqurashi, Yousef, Elsherif, Mohamed, Hendi, Asail, Essa, Khamis, Butt, Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773850/
https://www.ncbi.nlm.nih.gov/pubmed/35049668
http://dx.doi.org/10.3390/bios12010040
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author Alqurashi, Yousef
Elsherif, Mohamed
Hendi, Asail
Essa, Khamis
Butt, Haider
author_facet Alqurashi, Yousef
Elsherif, Mohamed
Hendi, Asail
Essa, Khamis
Butt, Haider
author_sort Alqurashi, Yousef
collection PubMed
description Measuring pH has become a major key for determining health conditions, and food safety. The traditional pH assessment approaches are costly and offer low sensitivity. Here, a novel pH sensor based on a pH-responsive hydrogel has been developed. A Fresnel lens pattern was replicated on the surface of the pH-responsive hydrogel using the replica mould method. The pH sensors were tested in a pH range of 4–7. Introducing various pH solutions to the pH sensor led to volumetric shifts as the hydrogel swelled with pH. Consequently, the dimensions of the replicated Fresnel lens changed, modifying the focal length and the focus efficiency of the optical sensor. As a result, the measured optical power at a fixed distance from the sensor changed with pH. The optical sensor showed the best performance in the acidic region when pH changed from 4.5 to 5.5, in which the recorded power increased by 13%. The sensor exhibited high sensitivity to pH changes with a short respond time in a reversible manner. The developed pH optical sensor may have applications in medical point-of-care diagnostics and wearable continuous pH detection devices.
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spelling pubmed-87738502022-01-21 Optical Hydrogel Detector for pH Measurements Alqurashi, Yousef Elsherif, Mohamed Hendi, Asail Essa, Khamis Butt, Haider Biosensors (Basel) Article Measuring pH has become a major key for determining health conditions, and food safety. The traditional pH assessment approaches are costly and offer low sensitivity. Here, a novel pH sensor based on a pH-responsive hydrogel has been developed. A Fresnel lens pattern was replicated on the surface of the pH-responsive hydrogel using the replica mould method. The pH sensors were tested in a pH range of 4–7. Introducing various pH solutions to the pH sensor led to volumetric shifts as the hydrogel swelled with pH. Consequently, the dimensions of the replicated Fresnel lens changed, modifying the focal length and the focus efficiency of the optical sensor. As a result, the measured optical power at a fixed distance from the sensor changed with pH. The optical sensor showed the best performance in the acidic region when pH changed from 4.5 to 5.5, in which the recorded power increased by 13%. The sensor exhibited high sensitivity to pH changes with a short respond time in a reversible manner. The developed pH optical sensor may have applications in medical point-of-care diagnostics and wearable continuous pH detection devices. MDPI 2022-01-13 /pmc/articles/PMC8773850/ /pubmed/35049668 http://dx.doi.org/10.3390/bios12010040 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alqurashi, Yousef
Elsherif, Mohamed
Hendi, Asail
Essa, Khamis
Butt, Haider
Optical Hydrogel Detector for pH Measurements
title Optical Hydrogel Detector for pH Measurements
title_full Optical Hydrogel Detector for pH Measurements
title_fullStr Optical Hydrogel Detector for pH Measurements
title_full_unstemmed Optical Hydrogel Detector for pH Measurements
title_short Optical Hydrogel Detector for pH Measurements
title_sort optical hydrogel detector for ph measurements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773850/
https://www.ncbi.nlm.nih.gov/pubmed/35049668
http://dx.doi.org/10.3390/bios12010040
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