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Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases

Mitochondria are multifunctional organelles that participate in a wide range of metabolic processes, including energy production and biomolecule synthesis. The morphology and distribution of intracellular mitochondria change dynamically, reflecting a cell’s metabolic activity. Oxidative stress is de...

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Autores principales: Kessas, Khadidja, Chouari, Zhor, Ghzaiel, Imen, Zarrouk, Amira, Ksila, Mohamed, Ghrairi, Taoufik, El Midaoui, Adil, Lizard, Gérard, Kharoubi, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773907/
https://www.ncbi.nlm.nih.gov/pubmed/35053373
http://dx.doi.org/10.3390/cells11020257
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author Kessas, Khadidja
Chouari, Zhor
Ghzaiel, Imen
Zarrouk, Amira
Ksila, Mohamed
Ghrairi, Taoufik
El Midaoui, Adil
Lizard, Gérard
Kharoubi, Omar
author_facet Kessas, Khadidja
Chouari, Zhor
Ghzaiel, Imen
Zarrouk, Amira
Ksila, Mohamed
Ghrairi, Taoufik
El Midaoui, Adil
Lizard, Gérard
Kharoubi, Omar
author_sort Kessas, Khadidja
collection PubMed
description Mitochondria are multifunctional organelles that participate in a wide range of metabolic processes, including energy production and biomolecule synthesis. The morphology and distribution of intracellular mitochondria change dynamically, reflecting a cell’s metabolic activity. Oxidative stress is defined as a mismatch between the body’s ability to neutralise and eliminate reactive oxygen and nitrogen species (ROS and RNS). A determination of mitochondria failure in increasing oxidative stress, as well as its implications in neurodegenerative illnesses and apoptosis, is a significant developmental process of focus in this review. The neuroprotective effects of bioactive compounds linked to neuronal regulation, as well as related neuronal development abnormalities, will be investigated. In conclusion, the study of secondary components and the use of mitochondrial features in the analysis of various neurodevelopmental diseases has enabled the development of a new class of mitochondrial-targeted pharmaceuticals capable of alleviating neurodegenerative disease states and enabling longevity and healthy ageing for the vast majority of people.
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spelling pubmed-87739072022-01-21 Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases Kessas, Khadidja Chouari, Zhor Ghzaiel, Imen Zarrouk, Amira Ksila, Mohamed Ghrairi, Taoufik El Midaoui, Adil Lizard, Gérard Kharoubi, Omar Cells Review Mitochondria are multifunctional organelles that participate in a wide range of metabolic processes, including energy production and biomolecule synthesis. The morphology and distribution of intracellular mitochondria change dynamically, reflecting a cell’s metabolic activity. Oxidative stress is defined as a mismatch between the body’s ability to neutralise and eliminate reactive oxygen and nitrogen species (ROS and RNS). A determination of mitochondria failure in increasing oxidative stress, as well as its implications in neurodegenerative illnesses and apoptosis, is a significant developmental process of focus in this review. The neuroprotective effects of bioactive compounds linked to neuronal regulation, as well as related neuronal development abnormalities, will be investigated. In conclusion, the study of secondary components and the use of mitochondrial features in the analysis of various neurodevelopmental diseases has enabled the development of a new class of mitochondrial-targeted pharmaceuticals capable of alleviating neurodegenerative disease states and enabling longevity and healthy ageing for the vast majority of people. MDPI 2022-01-13 /pmc/articles/PMC8773907/ /pubmed/35053373 http://dx.doi.org/10.3390/cells11020257 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kessas, Khadidja
Chouari, Zhor
Ghzaiel, Imen
Zarrouk, Amira
Ksila, Mohamed
Ghrairi, Taoufik
El Midaoui, Adil
Lizard, Gérard
Kharoubi, Omar
Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title_full Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title_fullStr Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title_full_unstemmed Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title_short Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
title_sort role of bioactive compounds in the regulation of mitochondrial dysfunctions in brain and age-related neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773907/
https://www.ncbi.nlm.nih.gov/pubmed/35053373
http://dx.doi.org/10.3390/cells11020257
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