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Sex-Related Factors in Cardiovascular Complications Associated to COVID-19

Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptib...

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Autores principales: Megiorni, Francesca, Pontecorvi, Paola, Gerini, Giulia, Anastasiadou, Eleni, Marchese, Cinzia, Ceccarelli, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773922/
https://www.ncbi.nlm.nih.gov/pubmed/35053169
http://dx.doi.org/10.3390/biom12010021
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author Megiorni, Francesca
Pontecorvi, Paola
Gerini, Giulia
Anastasiadou, Eleni
Marchese, Cinzia
Ceccarelli, Simona
author_facet Megiorni, Francesca
Pontecorvi, Paola
Gerini, Giulia
Anastasiadou, Eleni
Marchese, Cinzia
Ceccarelli, Simona
author_sort Megiorni, Francesca
collection PubMed
description Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptibility and mortality show a significant sex imbalance, with men being more prone to infection and showing a higher rate of hospitalization and mortality compared to women. Such variability can be ascribed to both sex-related biological factors and gender-related behavioral cues. This review will discuss the potential mechanisms accounting for sex/gender influence in vulnerability to COVID-19. Cardiovascular diseases play a central role in determining COVID-19 outcome, whether they are pre-existent or arose upon infection. We will pay particular attention to the impact of sex and gender on cardiovascular manifestations related to COVID-19. Finally, we will discuss the sex-dependent variability in some biomarkers for the evaluation of COVID-19 infection and prognosis. The aim of this work is to highlight the significance of gendered medicine in setting up personalized programs for COVID-19 prevention, clinical evaluation and treatment.
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spelling pubmed-87739222022-01-21 Sex-Related Factors in Cardiovascular Complications Associated to COVID-19 Megiorni, Francesca Pontecorvi, Paola Gerini, Giulia Anastasiadou, Eleni Marchese, Cinzia Ceccarelli, Simona Biomolecules Review Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptibility and mortality show a significant sex imbalance, with men being more prone to infection and showing a higher rate of hospitalization and mortality compared to women. Such variability can be ascribed to both sex-related biological factors and gender-related behavioral cues. This review will discuss the potential mechanisms accounting for sex/gender influence in vulnerability to COVID-19. Cardiovascular diseases play a central role in determining COVID-19 outcome, whether they are pre-existent or arose upon infection. We will pay particular attention to the impact of sex and gender on cardiovascular manifestations related to COVID-19. Finally, we will discuss the sex-dependent variability in some biomarkers for the evaluation of COVID-19 infection and prognosis. The aim of this work is to highlight the significance of gendered medicine in setting up personalized programs for COVID-19 prevention, clinical evaluation and treatment. MDPI 2021-12-24 /pmc/articles/PMC8773922/ /pubmed/35053169 http://dx.doi.org/10.3390/biom12010021 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Megiorni, Francesca
Pontecorvi, Paola
Gerini, Giulia
Anastasiadou, Eleni
Marchese, Cinzia
Ceccarelli, Simona
Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title_full Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title_fullStr Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title_full_unstemmed Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title_short Sex-Related Factors in Cardiovascular Complications Associated to COVID-19
title_sort sex-related factors in cardiovascular complications associated to covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773922/
https://www.ncbi.nlm.nih.gov/pubmed/35053169
http://dx.doi.org/10.3390/biom12010021
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