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Recurrent Spliceosome Mutations in Cancer: Mechanisms and Consequences of Aberrant Splice Site Selection

SIMPLE SUMMARY: The spliceosome ribonucleoprotein complex catalyzes the removal of introns and exons ligation, a fundamental post-transcriptional process that generates mature RNAs. Cancer-associated mutations in spliceosome components give rise to aberrant splice site selection and, therefore, the...

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Detalles Bibliográficos
Autores principales:	Niño, Carlos A., Scotto di Perrotolo, Rossella, Polo, Simona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773931/ https://www.ncbi.nlm.nih.gov/pubmed/35053445 http://dx.doi.org/10.3390/cancers14020281

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