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Nonwoven Textiles from Hyaluronan for Wound Healing Applications

Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocom...

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Detalles Bibliográficos
Autores principales: Kubíčková, Jolana, Medek, Tomáš, Husby, Jarmila, Matonohová, Jana, Vágnerová, Hana, Marholdová, Lucie, Velebný, Vladimír, Chmelař, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773973/
https://www.ncbi.nlm.nih.gov/pubmed/35053164
http://dx.doi.org/10.3390/biom12010016
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author Kubíčková, Jolana
Medek, Tomáš
Husby, Jarmila
Matonohová, Jana
Vágnerová, Hana
Marholdová, Lucie
Velebný, Vladimír
Chmelař, Josef
author_facet Kubíčková, Jolana
Medek, Tomáš
Husby, Jarmila
Matonohová, Jana
Vágnerová, Hana
Marholdová, Lucie
Velebný, Vladimír
Chmelař, Josef
author_sort Kubíčková, Jolana
collection PubMed
description Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocompatible, biodegradable and nontoxic polysaccharide naturally present in the human body. For this purpose, we used a process based on wet spinning HA into a nonstationary coagulation bath combined with the wet-laid textile technology. The obtained HA nonwoven textiles are soft, flexible and paper like. Their mechanical properties, handling and hydration depend on the microscale fibre structure, which is tuneable by selected process parameters. Cell viability testing on two relevant cell lines (3T3, HaCaT) demonstrated that the textiles are not cytotoxic, while the monocyte activation test ruled out pyrogenicity. Biocompatibility, biodegradability and their high capacity for moisture absorption make HA nonwoven textiles a promising material for applications in the field of wound healing, both for topical and internal use. The beneficial effect of HA in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds.
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spelling pubmed-87739732022-01-21 Nonwoven Textiles from Hyaluronan for Wound Healing Applications Kubíčková, Jolana Medek, Tomáš Husby, Jarmila Matonohová, Jana Vágnerová, Hana Marholdová, Lucie Velebný, Vladimír Chmelař, Josef Biomolecules Article Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocompatible, biodegradable and nontoxic polysaccharide naturally present in the human body. For this purpose, we used a process based on wet spinning HA into a nonstationary coagulation bath combined with the wet-laid textile technology. The obtained HA nonwoven textiles are soft, flexible and paper like. Their mechanical properties, handling and hydration depend on the microscale fibre structure, which is tuneable by selected process parameters. Cell viability testing on two relevant cell lines (3T3, HaCaT) demonstrated that the textiles are not cytotoxic, while the monocyte activation test ruled out pyrogenicity. Biocompatibility, biodegradability and their high capacity for moisture absorption make HA nonwoven textiles a promising material for applications in the field of wound healing, both for topical and internal use. The beneficial effect of HA in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds. MDPI 2021-12-23 /pmc/articles/PMC8773973/ /pubmed/35053164 http://dx.doi.org/10.3390/biom12010016 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kubíčková, Jolana
Medek, Tomáš
Husby, Jarmila
Matonohová, Jana
Vágnerová, Hana
Marholdová, Lucie
Velebný, Vladimír
Chmelař, Josef
Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title_full Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title_fullStr Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title_full_unstemmed Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title_short Nonwoven Textiles from Hyaluronan for Wound Healing Applications
title_sort nonwoven textiles from hyaluronan for wound healing applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773973/
https://www.ncbi.nlm.nih.gov/pubmed/35053164
http://dx.doi.org/10.3390/biom12010016
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