Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene

Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1–6% O(2)), known as hypoxia. For MM cells, hypoxia is a physiologic feat...

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Detalles Bibliográficos
Autores principales: Clees, Ada-Sophia, Stolp, Verena, Häupl, Björn, Fuhrmann, Dominik C., Wempe, Frank, Seibert, Marcel, Weber, Sarah, Banning, Antje, Tikkanen, Ritva, Williams, Richard, Brüne, Bernhard, Serve, Hubert, Schnütgen, Frank, von Metzler, Ivana, Kurrle, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773999/
https://www.ncbi.nlm.nih.gov/pubmed/35053409
http://dx.doi.org/10.3390/cells11020292

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