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Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells

The insulin-degrading enzyme (IDE) is a zinc-dependent metalloendopeptidase that belongs to the M16A metalloprotease family. IDE is markedly expressed in the brain, where it is particularly relevant due to its in vitro amyloid beta (Aβ)-degrading activity. The subcellular localization of IDE, a para...

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Detalles Bibliográficos
Autores principales:	Corraliza-Gómez, Miriam, Lillo, Concepción, Cózar-Castellano, Irene, Arranz, Eduardo, Sanchez, Diego, Ganfornina, Maria D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774118/ https://www.ncbi.nlm.nih.gov/pubmed/35053342 http://dx.doi.org/10.3390/cells11020227

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