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Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774176/ https://www.ncbi.nlm.nih.gov/pubmed/35053696 http://dx.doi.org/10.3390/children9010072 |
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author | Nissen, Matthias Rogge, Phillip Sander, Volker Alrefai, Mohamad Romanova, Anna Tröbs, Ralf-Bodo |
author_facet | Nissen, Matthias Rogge, Phillip Sander, Volker Alrefai, Mohamad Romanova, Anna Tröbs, Ralf-Bodo |
author_sort | Nissen, Matthias |
collection | PubMed |
description | Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns regarding symptoms and outcomes that may support the non-surgical treatment of UA. Methods: Retrospective review on the clinico-laboratory characteristics of 52 children aged < 17 years undergoing resection of symptomatic UA at our pediatric surgical unit during 2006–2017. Data was dichotomized into age > 1 (n = 17) versus < 1 year (n = 35), and complicated (pre-/post-surgical abscess formation or peritonitis, n = 10) versus non-complicated course (n = 42). Results: Children aged < 1 year comprised majority (67%) of cohort and had lower complication rates (p = 0.062). Complicated course at surgery exclusively occurred in patients aged > 1 year (p = 0.003). Additionally, complicated group was older (p = 0.018), displayed leukocytosis (p < 0.001) and higher frequencies regarding presence of abdominal pain (p = 0.008) and abdominal mass (p = 0.034) on admission. Regression analysis identified present abdominal pain (OR (95% CI), 11.121 (1.152–107.337); p = 0.037) and leukocytosis (1.435 (1.070–1.925); p = 0.016) being associated with complicated course. Conclusions: This study provides evidence that symptomatic disease course follows an age-dependent complication pattern with lower complication rates at age < 1 year. Larger, studies have to clarify, if waiting for spontaneous urachal obliteration during the first year of life comprises a reasonable alternative to surgery. |
format | Online Article Text |
id | pubmed-8774176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87741762022-01-21 Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature Nissen, Matthias Rogge, Phillip Sander, Volker Alrefai, Mohamad Romanova, Anna Tröbs, Ralf-Bodo Children (Basel) Article Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns regarding symptoms and outcomes that may support the non-surgical treatment of UA. Methods: Retrospective review on the clinico-laboratory characteristics of 52 children aged < 17 years undergoing resection of symptomatic UA at our pediatric surgical unit during 2006–2017. Data was dichotomized into age > 1 (n = 17) versus < 1 year (n = 35), and complicated (pre-/post-surgical abscess formation or peritonitis, n = 10) versus non-complicated course (n = 42). Results: Children aged < 1 year comprised majority (67%) of cohort and had lower complication rates (p = 0.062). Complicated course at surgery exclusively occurred in patients aged > 1 year (p = 0.003). Additionally, complicated group was older (p = 0.018), displayed leukocytosis (p < 0.001) and higher frequencies regarding presence of abdominal pain (p = 0.008) and abdominal mass (p = 0.034) on admission. Regression analysis identified present abdominal pain (OR (95% CI), 11.121 (1.152–107.337); p = 0.037) and leukocytosis (1.435 (1.070–1.925); p = 0.016) being associated with complicated course. Conclusions: This study provides evidence that symptomatic disease course follows an age-dependent complication pattern with lower complication rates at age < 1 year. Larger, studies have to clarify, if waiting for spontaneous urachal obliteration during the first year of life comprises a reasonable alternative to surgery. MDPI 2022-01-05 /pmc/articles/PMC8774176/ /pubmed/35053696 http://dx.doi.org/10.3390/children9010072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nissen, Matthias Rogge, Phillip Sander, Volker Alrefai, Mohamad Romanova, Anna Tröbs, Ralf-Bodo Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title | Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title_full | Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title_fullStr | Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title_full_unstemmed | Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title_short | Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature |
title_sort | pediatric urachal anomalies: monocentric experience and mini-review of literature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774176/ https://www.ncbi.nlm.nih.gov/pubmed/35053696 http://dx.doi.org/10.3390/children9010072 |
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