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Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature

Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns re...

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Autores principales: Nissen, Matthias, Rogge, Phillip, Sander, Volker, Alrefai, Mohamad, Romanova, Anna, Tröbs, Ralf-Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774176/
https://www.ncbi.nlm.nih.gov/pubmed/35053696
http://dx.doi.org/10.3390/children9010072
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author Nissen, Matthias
Rogge, Phillip
Sander, Volker
Alrefai, Mohamad
Romanova, Anna
Tröbs, Ralf-Bodo
author_facet Nissen, Matthias
Rogge, Phillip
Sander, Volker
Alrefai, Mohamad
Romanova, Anna
Tröbs, Ralf-Bodo
author_sort Nissen, Matthias
collection PubMed
description Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns regarding symptoms and outcomes that may support the non-surgical treatment of UA. Methods: Retrospective review on the clinico-laboratory characteristics of 52 children aged < 17 years undergoing resection of symptomatic UA at our pediatric surgical unit during 2006–2017. Data was dichotomized into age > 1 (n = 17) versus < 1 year (n = 35), and complicated (pre-/post-surgical abscess formation or peritonitis, n = 10) versus non-complicated course (n = 42). Results: Children aged < 1 year comprised majority (67%) of cohort and had lower complication rates (p = 0.062). Complicated course at surgery exclusively occurred in patients aged > 1 year (p = 0.003). Additionally, complicated group was older (p = 0.018), displayed leukocytosis (p < 0.001) and higher frequencies regarding presence of abdominal pain (p = 0.008) and abdominal mass (p = 0.034) on admission. Regression analysis identified present abdominal pain (OR (95% CI), 11.121 (1.152–107.337); p = 0.037) and leukocytosis (1.435 (1.070–1.925); p = 0.016) being associated with complicated course. Conclusions: This study provides evidence that symptomatic disease course follows an age-dependent complication pattern with lower complication rates at age < 1 year. Larger, studies have to clarify, if waiting for spontaneous urachal obliteration during the first year of life comprises a reasonable alternative to surgery.
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spelling pubmed-87741762022-01-21 Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature Nissen, Matthias Rogge, Phillip Sander, Volker Alrefai, Mohamad Romanova, Anna Tröbs, Ralf-Bodo Children (Basel) Article Background: Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns regarding symptoms and outcomes that may support the non-surgical treatment of UA. Methods: Retrospective review on the clinico-laboratory characteristics of 52 children aged < 17 years undergoing resection of symptomatic UA at our pediatric surgical unit during 2006–2017. Data was dichotomized into age > 1 (n = 17) versus < 1 year (n = 35), and complicated (pre-/post-surgical abscess formation or peritonitis, n = 10) versus non-complicated course (n = 42). Results: Children aged < 1 year comprised majority (67%) of cohort and had lower complication rates (p = 0.062). Complicated course at surgery exclusively occurred in patients aged > 1 year (p = 0.003). Additionally, complicated group was older (p = 0.018), displayed leukocytosis (p < 0.001) and higher frequencies regarding presence of abdominal pain (p = 0.008) and abdominal mass (p = 0.034) on admission. Regression analysis identified present abdominal pain (OR (95% CI), 11.121 (1.152–107.337); p = 0.037) and leukocytosis (1.435 (1.070–1.925); p = 0.016) being associated with complicated course. Conclusions: This study provides evidence that symptomatic disease course follows an age-dependent complication pattern with lower complication rates at age < 1 year. Larger, studies have to clarify, if waiting for spontaneous urachal obliteration during the first year of life comprises a reasonable alternative to surgery. MDPI 2022-01-05 /pmc/articles/PMC8774176/ /pubmed/35053696 http://dx.doi.org/10.3390/children9010072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nissen, Matthias
Rogge, Phillip
Sander, Volker
Alrefai, Mohamad
Romanova, Anna
Tröbs, Ralf-Bodo
Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title_full Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title_fullStr Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title_full_unstemmed Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title_short Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
title_sort pediatric urachal anomalies: monocentric experience and mini-review of literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774176/
https://www.ncbi.nlm.nih.gov/pubmed/35053696
http://dx.doi.org/10.3390/children9010072
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