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The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes
Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other di...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774208/ https://www.ncbi.nlm.nih.gov/pubmed/35053215 http://dx.doi.org/10.3390/biom12010067 |
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author | Kryvalap, Yury Czyzyk, Jan |
author_facet | Kryvalap, Yury Czyzyk, Jan |
author_sort | Kryvalap, Yury |
collection | PubMed |
description | Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibition or augmentation of protease activity can bring about positive outcomes in pancreatic islet biology and inflammation. These potential discrepancies can be reconciled at the molecular level as specific proteases and serpins regulate distinct signaling pathways, thereby playing equally distinct roles in health and disease development. |
format | Online Article Text |
id | pubmed-8774208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87742082022-01-21 The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes Kryvalap, Yury Czyzyk, Jan Biomolecules Review Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibition or augmentation of protease activity can bring about positive outcomes in pancreatic islet biology and inflammation. These potential discrepancies can be reconciled at the molecular level as specific proteases and serpins regulate distinct signaling pathways, thereby playing equally distinct roles in health and disease development. MDPI 2022-01-02 /pmc/articles/PMC8774208/ /pubmed/35053215 http://dx.doi.org/10.3390/biom12010067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kryvalap, Yury Czyzyk, Jan The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title_full | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title_fullStr | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title_full_unstemmed | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title_short | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
title_sort | role of proteases and serpin protease inhibitors in β-cell biology and diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774208/ https://www.ncbi.nlm.nih.gov/pubmed/35053215 http://dx.doi.org/10.3390/biom12010067 |
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