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CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone

Due to their similar imaging features, high-grade gliomas (HGGs) and solitary brain metastases (BMs) can be easily misclassified. The peritumoral zone (PZ) of HGGs develops neoplastic cell infiltration, while in BMs the PZ contains pure vasogenic edema. As the two PZs cannot be differentiated macros...

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Autores principales: Mărginean, Lucian, Ștefan, Paul Andrei, Lebovici, Andrei, Opincariu, Iulian, Csutak, Csaba, Lupean, Roxana Adelina, Coroian, Paul Alexandru, Suciu, Bogdan Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774238/
https://www.ncbi.nlm.nih.gov/pubmed/35053852
http://dx.doi.org/10.3390/brainsci12010109
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author Mărginean, Lucian
Ștefan, Paul Andrei
Lebovici, Andrei
Opincariu, Iulian
Csutak, Csaba
Lupean, Roxana Adelina
Coroian, Paul Alexandru
Suciu, Bogdan Andrei
author_facet Mărginean, Lucian
Ștefan, Paul Andrei
Lebovici, Andrei
Opincariu, Iulian
Csutak, Csaba
Lupean, Roxana Adelina
Coroian, Paul Alexandru
Suciu, Bogdan Andrei
author_sort Mărginean, Lucian
collection PubMed
description Due to their similar imaging features, high-grade gliomas (HGGs) and solitary brain metastases (BMs) can be easily misclassified. The peritumoral zone (PZ) of HGGs develops neoplastic cell infiltration, while in BMs the PZ contains pure vasogenic edema. As the two PZs cannot be differentiated macroscopically, this study investigated whether computed tomography (CT)-based texture analysis (TA) of the PZ can reflect the histological difference between the two entities. Thirty-six patients with solitary brain tumors (HGGs, n = 17; BMs, n = 19) that underwent CT examinations were retrospectively included in this pilot study. TA of the PZ was analyzed using dedicated software (MaZda version 5). Univariate, multivariate, and receiver operating characteristics analyses were used to identify the best-suited parameters for distinguishing between the two groups. Seven texture parameters were able to differentiate between HGGs and BMs with variable sensitivity (56.67–96.67%) and specificity (69.23–100%) rates. Their combined ability successfully identified HGGs with 77.9–99.2% sensitivity and 75.3–100% specificity. In conclusion, the CT-based TA can be a useful tool for differentiating between primary and secondary malignancies. The TA features indicate a more heterogenous content of the HGGs’ PZ, possibly due to the local infiltration of neoplastic cells.
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spelling pubmed-87742382022-01-21 CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone Mărginean, Lucian Ștefan, Paul Andrei Lebovici, Andrei Opincariu, Iulian Csutak, Csaba Lupean, Roxana Adelina Coroian, Paul Alexandru Suciu, Bogdan Andrei Brain Sci Article Due to their similar imaging features, high-grade gliomas (HGGs) and solitary brain metastases (BMs) can be easily misclassified. The peritumoral zone (PZ) of HGGs develops neoplastic cell infiltration, while in BMs the PZ contains pure vasogenic edema. As the two PZs cannot be differentiated macroscopically, this study investigated whether computed tomography (CT)-based texture analysis (TA) of the PZ can reflect the histological difference between the two entities. Thirty-six patients with solitary brain tumors (HGGs, n = 17; BMs, n = 19) that underwent CT examinations were retrospectively included in this pilot study. TA of the PZ was analyzed using dedicated software (MaZda version 5). Univariate, multivariate, and receiver operating characteristics analyses were used to identify the best-suited parameters for distinguishing between the two groups. Seven texture parameters were able to differentiate between HGGs and BMs with variable sensitivity (56.67–96.67%) and specificity (69.23–100%) rates. Their combined ability successfully identified HGGs with 77.9–99.2% sensitivity and 75.3–100% specificity. In conclusion, the CT-based TA can be a useful tool for differentiating between primary and secondary malignancies. The TA features indicate a more heterogenous content of the HGGs’ PZ, possibly due to the local infiltration of neoplastic cells. MDPI 2022-01-14 /pmc/articles/PMC8774238/ /pubmed/35053852 http://dx.doi.org/10.3390/brainsci12010109 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mărginean, Lucian
Ștefan, Paul Andrei
Lebovici, Andrei
Opincariu, Iulian
Csutak, Csaba
Lupean, Roxana Adelina
Coroian, Paul Alexandru
Suciu, Bogdan Andrei
CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title_full CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title_fullStr CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title_full_unstemmed CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title_short CT in the Differentiation of Gliomas from Brain Metastases: The Radiomics Analysis of the Peritumoral Zone
title_sort ct in the differentiation of gliomas from brain metastases: the radiomics analysis of the peritumoral zone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774238/
https://www.ncbi.nlm.nih.gov/pubmed/35053852
http://dx.doi.org/10.3390/brainsci12010109
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