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Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel
The challenges encountered with conventional microbicide gels has necessitated the quest for alternative options. This study aimed to formulate and evaluate a bigel and thermosensitive gel, designed to combat the challenges of leakage and short-residence time in the vagina. Ionic-gelation technique...
Autores principales: | Ekama, Sabdat Ozichu, Ilomuanya, Margaret O., Azubuike, Chukwuemeka Paul, Ayorinde, James Babatunde, Ezechi, Oliver Chukwujekwu, Igwilo, Cecilia Ihuoma, Salako, Babatunde Lawal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774413/ https://www.ncbi.nlm.nih.gov/pubmed/35049550 http://dx.doi.org/10.3390/gels8010015 |
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