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First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania

Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditio...

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Autores principales: Stan, Iustina Violeta, Miron, Victor Daniel, Vangheli, Ioana Alexandra, Gheorghiu, Radu Marian, Streinu-Cercel, Anca, Săndulescu, Oana, Craiu, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774439/
https://www.ncbi.nlm.nih.gov/pubmed/35054306
http://dx.doi.org/10.3390/diagnostics12010137
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author Stan, Iustina Violeta
Miron, Victor Daniel
Vangheli, Ioana Alexandra
Gheorghiu, Radu Marian
Streinu-Cercel, Anca
Săndulescu, Oana
Craiu, Mihai
author_facet Stan, Iustina Violeta
Miron, Victor Daniel
Vangheli, Ioana Alexandra
Gheorghiu, Radu Marian
Streinu-Cercel, Anca
Săndulescu, Oana
Craiu, Mihai
author_sort Stan, Iustina Violeta
collection PubMed
description Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditions (bronchiectasis, exocrine pancreatic insufficiency, chronic multidrug resistant Pseudomonas aeruginosa colonization, nasal polyposis, chronic sinusitis, ventricular extrasystoles and multiple drug allergies), who presented with an acute episode of productive cough, and was confirmed with moderate COVID-19 based on positive RT-PCR for SARS-CoV-2 and lung imaging showing isolated foci of interstitial pneumonia. Intravenous treatment with the monoclonal antibody cocktail casirivimab and imdevimab was administered. The evolution was favorable, with rapid remission of the inflammatory syndrome and gradual decrease of cough, without progression to severe or critical COVID-19, but with complications such as repeated hemoptysis, which was due to the patient’s underlying conditions, and which required close monitoring for timely adjustment of the patient’s chronic treatment.
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spelling pubmed-87744392022-01-21 First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania Stan, Iustina Violeta Miron, Victor Daniel Vangheli, Ioana Alexandra Gheorghiu, Radu Marian Streinu-Cercel, Anca Săndulescu, Oana Craiu, Mihai Diagnostics (Basel) Case Report Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditions (bronchiectasis, exocrine pancreatic insufficiency, chronic multidrug resistant Pseudomonas aeruginosa colonization, nasal polyposis, chronic sinusitis, ventricular extrasystoles and multiple drug allergies), who presented with an acute episode of productive cough, and was confirmed with moderate COVID-19 based on positive RT-PCR for SARS-CoV-2 and lung imaging showing isolated foci of interstitial pneumonia. Intravenous treatment with the monoclonal antibody cocktail casirivimab and imdevimab was administered. The evolution was favorable, with rapid remission of the inflammatory syndrome and gradual decrease of cough, without progression to severe or critical COVID-19, but with complications such as repeated hemoptysis, which was due to the patient’s underlying conditions, and which required close monitoring for timely adjustment of the patient’s chronic treatment. MDPI 2022-01-07 /pmc/articles/PMC8774439/ /pubmed/35054306 http://dx.doi.org/10.3390/diagnostics12010137 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Stan, Iustina Violeta
Miron, Victor Daniel
Vangheli, Ioana Alexandra
Gheorghiu, Radu Marian
Streinu-Cercel, Anca
Săndulescu, Oana
Craiu, Mihai
First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title_full First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title_fullStr First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title_full_unstemmed First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title_short First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
title_sort first case of covid-19 treated with monoclonal anti-spike antibodies in a patient with cystic fibrosis in romania
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774439/
https://www.ncbi.nlm.nih.gov/pubmed/35054306
http://dx.doi.org/10.3390/diagnostics12010137
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