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Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences

The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutriti...

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Autores principales: Peral-Sanchez, Irene, Hojeij, Batoul, Ojeda, Diego A., Steegers-Theunissen, Régine P. M., Willaime-Morawek, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774448/
https://www.ncbi.nlm.nih.gov/pubmed/35052371
http://dx.doi.org/10.3390/genes13010031
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author Peral-Sanchez, Irene
Hojeij, Batoul
Ojeda, Diego A.
Steegers-Theunissen, Régine P. M.
Willaime-Morawek, Sandrine
author_facet Peral-Sanchez, Irene
Hojeij, Batoul
Ojeda, Diego A.
Steegers-Theunissen, Régine P. M.
Willaime-Morawek, Sandrine
author_sort Peral-Sanchez, Irene
collection PubMed
description The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutritional status can affect embryonic development. This review summarises the main epigenetic modifications in mammals, especially DNA methylation, histone modifications, and ncRNA. These epigenetic changes can compromise the health of the offspring later in life. We discuss different types of nutritional stressors in human and animal models, such as maternal undernutrition, seasonal diets, low-protein diet, high-fat diet, and synthetic folic acid supplement use, and how these nutritional exposures epigenetically affect target genes and their outcomes. In addition, we review the concept of thrifty genes during the preimplantation period, and some examples that relate to epigenetic change and diet. Finally, we discuss different examples of maternal diets, their effect on outcomes, and their relationship with assisted reproductive technology (ART), including their implications on epigenetic modifications.
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spelling pubmed-87744482022-01-21 Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences Peral-Sanchez, Irene Hojeij, Batoul Ojeda, Diego A. Steegers-Theunissen, Régine P. M. Willaime-Morawek, Sandrine Genes (Basel) Review The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutritional status can affect embryonic development. This review summarises the main epigenetic modifications in mammals, especially DNA methylation, histone modifications, and ncRNA. These epigenetic changes can compromise the health of the offspring later in life. We discuss different types of nutritional stressors in human and animal models, such as maternal undernutrition, seasonal diets, low-protein diet, high-fat diet, and synthetic folic acid supplement use, and how these nutritional exposures epigenetically affect target genes and their outcomes. In addition, we review the concept of thrifty genes during the preimplantation period, and some examples that relate to epigenetic change and diet. Finally, we discuss different examples of maternal diets, their effect on outcomes, and their relationship with assisted reproductive technology (ART), including their implications on epigenetic modifications. MDPI 2021-12-23 /pmc/articles/PMC8774448/ /pubmed/35052371 http://dx.doi.org/10.3390/genes13010031 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peral-Sanchez, Irene
Hojeij, Batoul
Ojeda, Diego A.
Steegers-Theunissen, Régine P. M.
Willaime-Morawek, Sandrine
Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title_full Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title_fullStr Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title_full_unstemmed Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title_short Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
title_sort epigenetics in the uterine environment: how maternal diet and art may influence the epigenome in the offspring with long-term health consequences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774448/
https://www.ncbi.nlm.nih.gov/pubmed/35052371
http://dx.doi.org/10.3390/genes13010031
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