Cargando…
Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promis...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774477/ https://www.ncbi.nlm.nih.gov/pubmed/35049575 http://dx.doi.org/10.3390/gels8010040 |
_version_ | 1784636356180312064 |
---|---|
author | Tejo-Otero, Aitor Fenollosa-Artés, Felip Achaerandio, Isabel Rey-Vinolas, Sergi Buj-Corral, Irene Mateos-Timoneda, Miguel Ángel Engel, Elisabeth |
author_facet | Tejo-Otero, Aitor Fenollosa-Artés, Felip Achaerandio, Isabel Rey-Vinolas, Sergi Buj-Corral, Irene Mateos-Timoneda, Miguel Ángel Engel, Elisabeth |
author_sort | Tejo-Otero, Aitor |
collection | PubMed |
description | With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promising solution to simulate biological bodies. For this reason, to advance in the state-of-the-art a wide range of organs (e.g., liver, heart, kidney as well as brain) and hydrogels (e.g., agarose, polyvinyl alcohol –PVA–, Phytagel –PHY– and methacrylate gelatine –GelMA–) were tested regarding their mechanical properties. For that, viscoelastic behavior, hardness, as well as a non-linear elastic mechanical response were measured. It was seen that there was a significant difference among the results for the different mentioned soft tissues. Some of them appear to be more elastic than viscous as well as being softer or harder. With all this information in mind, a correlation between the mechanical properties of the organs and the different materials was performed. The next conclusions were drawn: (1) to mimic the liver, the best material is 1% wt agarose; (2) to mimic the heart, the best material is 2% wt agarose; (3) to mimic the kidney, the best material is 4% wt GelMA; and (4) to mimic the brain, the best materials are 4% wt GelMA and 1% wt agarose. Neither PVA nor PHY was selected to mimic any of the studied tissues. |
format | Online Article Text |
id | pubmed-8774477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87744772022-01-21 Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms Tejo-Otero, Aitor Fenollosa-Artés, Felip Achaerandio, Isabel Rey-Vinolas, Sergi Buj-Corral, Irene Mateos-Timoneda, Miguel Ángel Engel, Elisabeth Gels Article With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promising solution to simulate biological bodies. For this reason, to advance in the state-of-the-art a wide range of organs (e.g., liver, heart, kidney as well as brain) and hydrogels (e.g., agarose, polyvinyl alcohol –PVA–, Phytagel –PHY– and methacrylate gelatine –GelMA–) were tested regarding their mechanical properties. For that, viscoelastic behavior, hardness, as well as a non-linear elastic mechanical response were measured. It was seen that there was a significant difference among the results for the different mentioned soft tissues. Some of them appear to be more elastic than viscous as well as being softer or harder. With all this information in mind, a correlation between the mechanical properties of the organs and the different materials was performed. The next conclusions were drawn: (1) to mimic the liver, the best material is 1% wt agarose; (2) to mimic the heart, the best material is 2% wt agarose; (3) to mimic the kidney, the best material is 4% wt GelMA; and (4) to mimic the brain, the best materials are 4% wt GelMA and 1% wt agarose. Neither PVA nor PHY was selected to mimic any of the studied tissues. MDPI 2022-01-06 /pmc/articles/PMC8774477/ /pubmed/35049575 http://dx.doi.org/10.3390/gels8010040 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tejo-Otero, Aitor Fenollosa-Artés, Felip Achaerandio, Isabel Rey-Vinolas, Sergi Buj-Corral, Irene Mateos-Timoneda, Miguel Ángel Engel, Elisabeth Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title | Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title_full | Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title_fullStr | Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title_full_unstemmed | Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title_short | Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms |
title_sort | soft-tissue-mimicking using hydrogels for the development of phantoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774477/ https://www.ncbi.nlm.nih.gov/pubmed/35049575 http://dx.doi.org/10.3390/gels8010040 |
work_keys_str_mv | AT tejooteroaitor softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT fenollosaartesfelip softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT achaerandioisabel softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT reyvinolassergi softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT bujcorralirene softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT mateostimonedamiguelangel softtissuemimickingusinghydrogelsforthedevelopmentofphantoms AT engelelisabeth softtissuemimickingusinghydrogelsforthedevelopmentofphantoms |