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HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins

HAUSP (herpes virus-associated ubiquitin-specific protease), also known as Ubiquitin Specific Protease 7, plays critical roles in cellular processes, such as chromatin biology and epigenetics, through the regulation of different signaling pathways. HAUSP is a main partner of the “Epigenetic Code Rep...

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Autores principales: Abdullah, Omeima, Alhosin, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774506/
https://www.ncbi.nlm.nih.gov/pubmed/35052383
http://dx.doi.org/10.3390/genes13010042
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author Abdullah, Omeima
Alhosin, Mahmoud
author_facet Abdullah, Omeima
Alhosin, Mahmoud
author_sort Abdullah, Omeima
collection PubMed
description HAUSP (herpes virus-associated ubiquitin-specific protease), also known as Ubiquitin Specific Protease 7, plays critical roles in cellular processes, such as chromatin biology and epigenetics, through the regulation of different signaling pathways. HAUSP is a main partner of the “Epigenetic Code Replication Machinery,” ECREM, a large protein complex that includes several epigenetic players, such as the ubiquitin-like containing plant homeodomain (PHD) and an interesting new gene (RING), finger domains 1 (UHRF1), as well as DNA methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), histone methyltransferase G9a, and histone acetyltransferase TIP60. Due to its deubiquitinase activity and its ability to team up through direct interactions with several epigenetic regulators, mainly UHRF1, DNMT1, TIP60, the histone lysine methyltransferase EZH2, and the lysine-specific histone demethylase LSD1, HAUSP positions itself at the top of the regulatory hierarchies involved in epigenetic silencing of tumor suppressor genes in cancer. This review highlights the increasing role of HAUSP as an epigenetic master regulator that governs a set of epigenetic players involved in both the maintenance of DNA methylation and histone post-translational modifications.
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spelling pubmed-87745062022-01-21 HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins Abdullah, Omeima Alhosin, Mahmoud Genes (Basel) Review HAUSP (herpes virus-associated ubiquitin-specific protease), also known as Ubiquitin Specific Protease 7, plays critical roles in cellular processes, such as chromatin biology and epigenetics, through the regulation of different signaling pathways. HAUSP is a main partner of the “Epigenetic Code Replication Machinery,” ECREM, a large protein complex that includes several epigenetic players, such as the ubiquitin-like containing plant homeodomain (PHD) and an interesting new gene (RING), finger domains 1 (UHRF1), as well as DNA methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), histone methyltransferase G9a, and histone acetyltransferase TIP60. Due to its deubiquitinase activity and its ability to team up through direct interactions with several epigenetic regulators, mainly UHRF1, DNMT1, TIP60, the histone lysine methyltransferase EZH2, and the lysine-specific histone demethylase LSD1, HAUSP positions itself at the top of the regulatory hierarchies involved in epigenetic silencing of tumor suppressor genes in cancer. This review highlights the increasing role of HAUSP as an epigenetic master regulator that governs a set of epigenetic players involved in both the maintenance of DNA methylation and histone post-translational modifications. MDPI 2021-12-24 /pmc/articles/PMC8774506/ /pubmed/35052383 http://dx.doi.org/10.3390/genes13010042 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdullah, Omeima
Alhosin, Mahmoud
HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title_full HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title_fullStr HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title_full_unstemmed HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title_short HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
title_sort hausp is a key epigenetic regulator of the chromatin effector proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774506/
https://www.ncbi.nlm.nih.gov/pubmed/35052383
http://dx.doi.org/10.3390/genes13010042
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