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Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study

Purpose: To evaluate retinal and optic nerve head (ONH) perfusion in patients with atrial fibrillation (AF) before and after catheter ablation of AF with pulmonary vein isolation (PVI). Methods: 34 eyes of 34 patients with AF and 35 eyes of 35 healthy subjects were included in this study. Flow densi...

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Autores principales: Lange, Philipp S., Mihailovic, Natasa, Esser, Eliane, Frommeyer, Gerrit, Fischer, Alicia J., Bode, Niklas, Höwel, Dennis, Rosenberger, Friederike, Eter, Nicole, Eckardt, Lars, Lahme, Larissa, Alnawaiseh, Maged
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774642/
https://www.ncbi.nlm.nih.gov/pubmed/35054205
http://dx.doi.org/10.3390/diagnostics12010038
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author Lange, Philipp S.
Mihailovic, Natasa
Esser, Eliane
Frommeyer, Gerrit
Fischer, Alicia J.
Bode, Niklas
Höwel, Dennis
Rosenberger, Friederike
Eter, Nicole
Eckardt, Lars
Lahme, Larissa
Alnawaiseh, Maged
author_facet Lange, Philipp S.
Mihailovic, Natasa
Esser, Eliane
Frommeyer, Gerrit
Fischer, Alicia J.
Bode, Niklas
Höwel, Dennis
Rosenberger, Friederike
Eter, Nicole
Eckardt, Lars
Lahme, Larissa
Alnawaiseh, Maged
author_sort Lange, Philipp S.
collection PubMed
description Purpose: To evaluate retinal and optic nerve head (ONH) perfusion in patients with atrial fibrillation (AF) before and after catheter ablation of AF with pulmonary vein isolation (PVI). Methods: 34 eyes of 34 patients with AF and 35 eyes of 35 healthy subjects were included in this study. Flow density data were obtained using spectral-domain OCT-A (RTVue XR Avanti with AngioVue, Optovue, Inc, Fremont, California, USA). The data of the superficial and deep vascular layers of the macula and the ONH (radial peripapillary capillary network, RPC) before and after PVI were extracted and analysed. Results: The flow density in the superficial OCT-angiogram (whole en face) and the ONH (RPC) in patients with AF was significantly lower compared to healthy controls (OCT-A superficial: study group: 48.77 (45.19; 52.12)%; control group: 53.01 (50.00; 54.25)%; p < 0.001; ONH: study group: 51.82 (48.41; 54.03)%; control group: 56.00 (54.35; 57.70)%; p < 0.001;). The flow density in the ONH (RPC) improved significantly in the study group following PVI (before: 51.82 (48.41; 54.03)%; after: 52.49 (50.34; 55.62)%; p = 0.007). Conclusions: Patients with AF showed altered ocular perfusion as measured using OCTA when compared with healthy controls. Rhythm control using PVI significantly improved ocular perfusion as measured using OCT-A. Non-contact imaging using OCTA provides novel information about the central global microperfusion of patients with AF.
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spelling pubmed-87746422022-01-21 Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study Lange, Philipp S. Mihailovic, Natasa Esser, Eliane Frommeyer, Gerrit Fischer, Alicia J. Bode, Niklas Höwel, Dennis Rosenberger, Friederike Eter, Nicole Eckardt, Lars Lahme, Larissa Alnawaiseh, Maged Diagnostics (Basel) Article Purpose: To evaluate retinal and optic nerve head (ONH) perfusion in patients with atrial fibrillation (AF) before and after catheter ablation of AF with pulmonary vein isolation (PVI). Methods: 34 eyes of 34 patients with AF and 35 eyes of 35 healthy subjects were included in this study. Flow density data were obtained using spectral-domain OCT-A (RTVue XR Avanti with AngioVue, Optovue, Inc, Fremont, California, USA). The data of the superficial and deep vascular layers of the macula and the ONH (radial peripapillary capillary network, RPC) before and after PVI were extracted and analysed. Results: The flow density in the superficial OCT-angiogram (whole en face) and the ONH (RPC) in patients with AF was significantly lower compared to healthy controls (OCT-A superficial: study group: 48.77 (45.19; 52.12)%; control group: 53.01 (50.00; 54.25)%; p < 0.001; ONH: study group: 51.82 (48.41; 54.03)%; control group: 56.00 (54.35; 57.70)%; p < 0.001;). The flow density in the ONH (RPC) improved significantly in the study group following PVI (before: 51.82 (48.41; 54.03)%; after: 52.49 (50.34; 55.62)%; p = 0.007). Conclusions: Patients with AF showed altered ocular perfusion as measured using OCTA when compared with healthy controls. Rhythm control using PVI significantly improved ocular perfusion as measured using OCT-A. Non-contact imaging using OCTA provides novel information about the central global microperfusion of patients with AF. MDPI 2021-12-24 /pmc/articles/PMC8774642/ /pubmed/35054205 http://dx.doi.org/10.3390/diagnostics12010038 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lange, Philipp S.
Mihailovic, Natasa
Esser, Eliane
Frommeyer, Gerrit
Fischer, Alicia J.
Bode, Niklas
Höwel, Dennis
Rosenberger, Friederike
Eter, Nicole
Eckardt, Lars
Lahme, Larissa
Alnawaiseh, Maged
Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title_full Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title_fullStr Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title_full_unstemmed Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title_short Improvement of Retinal Microcirculation after Pulmonary Vein Isolation in Patients with Atrial Fibrillation—An Optical Coherence Tomography Angiography Study
title_sort improvement of retinal microcirculation after pulmonary vein isolation in patients with atrial fibrillation—an optical coherence tomography angiography study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774642/
https://www.ncbi.nlm.nih.gov/pubmed/35054205
http://dx.doi.org/10.3390/diagnostics12010038
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