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Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape

When DNA from a suspect is detected in a sample collected at a crime scene, there can be alternative explanations about the activity that may have led to the transfer, persistence and recovery of his/her DNA. Previous studies have shown that DNA can be indirectly transferred via intermediate surface...

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Detalles Bibliográficos
Autores principales: Fonneløp, Ane Elida, Faria, Sara, Shanthan, Gnanagowry, Gill, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774669/
https://www.ncbi.nlm.nih.gov/pubmed/35052357
http://dx.doi.org/10.3390/genes13010018
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author Fonneløp, Ane Elida
Faria, Sara
Shanthan, Gnanagowry
Gill, Peter
author_facet Fonneløp, Ane Elida
Faria, Sara
Shanthan, Gnanagowry
Gill, Peter
author_sort Fonneløp, Ane Elida
collection PubMed
description When DNA from a suspect is detected in a sample collected at a crime scene, there can be alternative explanations about the activity that may have led to the transfer, persistence and recovery of his/her DNA. Previous studies have shown that DNA can be indirectly transferred via intermediate surfaces and that DNA on a previously used object can persist after subsequent use of another individual. In addition, it has been shown that a person’s shedder status may influence transfer, persistence, prevalence, and recovery of DNA. In this study we have investigated transfer persistence and recovery on zip-lock bags and tape, which are commonly encountered in drug cases and how the shedder status of the participants influenced the results. A probabilistic framework was developed which was based on a previously described Bayesian network with case-specific modifications. Continuous modelling of data was used to inform the Bayesian networks and two case scenarios were investigated. In the specific scenarios only moderate to low support for H(p) was obtained. Applying a continuous model based on the profile quality can change the LRs.
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spelling pubmed-87746692022-01-21 Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape Fonneløp, Ane Elida Faria, Sara Shanthan, Gnanagowry Gill, Peter Genes (Basel) Article When DNA from a suspect is detected in a sample collected at a crime scene, there can be alternative explanations about the activity that may have led to the transfer, persistence and recovery of his/her DNA. Previous studies have shown that DNA can be indirectly transferred via intermediate surfaces and that DNA on a previously used object can persist after subsequent use of another individual. In addition, it has been shown that a person’s shedder status may influence transfer, persistence, prevalence, and recovery of DNA. In this study we have investigated transfer persistence and recovery on zip-lock bags and tape, which are commonly encountered in drug cases and how the shedder status of the participants influenced the results. A probabilistic framework was developed which was based on a previously described Bayesian network with case-specific modifications. Continuous modelling of data was used to inform the Bayesian networks and two case scenarios were investigated. In the specific scenarios only moderate to low support for H(p) was obtained. Applying a continuous model based on the profile quality can change the LRs. MDPI 2021-12-22 /pmc/articles/PMC8774669/ /pubmed/35052357 http://dx.doi.org/10.3390/genes13010018 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fonneløp, Ane Elida
Faria, Sara
Shanthan, Gnanagowry
Gill, Peter
Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title_full Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title_fullStr Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title_full_unstemmed Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title_short Who Packed the Drugs? Application of Bayesian Networks to Address Questions of DNA Transfer, Persistence, and Recovery from Plastic Bags and Tape
title_sort who packed the drugs? application of bayesian networks to address questions of dna transfer, persistence, and recovery from plastic bags and tape
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774669/
https://www.ncbi.nlm.nih.gov/pubmed/35052357
http://dx.doi.org/10.3390/genes13010018
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