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Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time

Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score...

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Autores principales: Tsapanou, Angeliki, Mourtzi, Niki, Charisis, Sokratis, Hatzimanolis, Alex, Ntanasi, Eva, Kosmidis, Mary H., Yannakoulia, Mary, Hadjigeorgiou, Georgios, Dardiotis, Efthimios, Sakka, Paraskevi, Stern, Yaakov, Scarmeas, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774850/
https://www.ncbi.nlm.nih.gov/pubmed/35052403
http://dx.doi.org/10.3390/genes13010063
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author Tsapanou, Angeliki
Mourtzi, Niki
Charisis, Sokratis
Hatzimanolis, Alex
Ntanasi, Eva
Kosmidis, Mary H.
Yannakoulia, Mary
Hadjigeorgiou, Georgios
Dardiotis, Efthimios
Sakka, Paraskevi
Stern, Yaakov
Scarmeas, Nikolaos
author_facet Tsapanou, Angeliki
Mourtzi, Niki
Charisis, Sokratis
Hatzimanolis, Alex
Ntanasi, Eva
Kosmidis, Mary H.
Yannakoulia, Mary
Hadjigeorgiou, Georgios
Dardiotis, Efthimios
Sakka, Paraskevi
Stern, Yaakov
Scarmeas, Nikolaos
author_sort Tsapanou, Angeliki
collection PubMed
description Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, ApolipoproteinE-ε4 genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, p = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, p = 0.018) and the adjusted for the covariates model (B = −1273.59, p = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, p = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health.
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spelling pubmed-87748502022-01-21 Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time Tsapanou, Angeliki Mourtzi, Niki Charisis, Sokratis Hatzimanolis, Alex Ntanasi, Eva Kosmidis, Mary H. Yannakoulia, Mary Hadjigeorgiou, Georgios Dardiotis, Efthimios Sakka, Paraskevi Stern, Yaakov Scarmeas, Nikolaos Genes (Basel) Article Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, ApolipoproteinE-ε4 genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, p = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, p = 0.018) and the adjusted for the covariates model (B = −1273.59, p = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, p = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health. MDPI 2021-12-27 /pmc/articles/PMC8774850/ /pubmed/35052403 http://dx.doi.org/10.3390/genes13010063 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsapanou, Angeliki
Mourtzi, Niki
Charisis, Sokratis
Hatzimanolis, Alex
Ntanasi, Eva
Kosmidis, Mary H.
Yannakoulia, Mary
Hadjigeorgiou, Georgios
Dardiotis, Efthimios
Sakka, Paraskevi
Stern, Yaakov
Scarmeas, Nikolaos
Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title_full Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title_fullStr Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title_full_unstemmed Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title_short Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
title_sort sleep polygenic risk score is associated with cognitive changes over time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774850/
https://www.ncbi.nlm.nih.gov/pubmed/35052403
http://dx.doi.org/10.3390/genes13010063
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