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Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective:...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774871/ https://www.ncbi.nlm.nih.gov/pubmed/35054358 http://dx.doi.org/10.3390/diagnostics12010191 |
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author | Beck, Janina Jaekel, Anke Kirsten Zeller, Federico Leopoldo Kowollik, Michael Kurze, Ines Kaufmann, Albert Feneberg, Wolfgang Brandt, Anna Flachenecker, Peter Henze, Thomas Domurath, Burkhard Schmidt, Paul Vance, Will Nelson Goldschmidt, Franziska Kirschner-Hermanns, Ruth Klara Maria Knüpfer, Stephanie C. |
author_facet | Beck, Janina Jaekel, Anke Kirsten Zeller, Federico Leopoldo Kowollik, Michael Kurze, Ines Kaufmann, Albert Feneberg, Wolfgang Brandt, Anna Flachenecker, Peter Henze, Thomas Domurath, Burkhard Schmidt, Paul Vance, Will Nelson Goldschmidt, Franziska Kirschner-Hermanns, Ruth Klara Maria Knüpfer, Stephanie C. |
author_sort | Beck, Janina |
collection | PubMed |
description | Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective: We aimed to identify clinical parameters indicative of neurogenic lower urinary tract dysfunction in multiple sclerosis patients. Methods: 207 patients were prospectively assessed independent of the presence of lower urinary tract symptoms. We analyzed Expanded Disability Status Scale scores, uroflowmetry, post-void residual, rate of urinary tract infections, standardized voiding frequency, and voided volume in correlation with urodynamic findings. Results: We found a significant correlation between post-void residual (odds ratio (OR) 4.17, confidence interval (CI) 1.20–22.46), urinary tract infection rate (OR 3.91, CI 1.13–21.0), voided volume (OR 4.53, CI 1.85–11.99), increased standardized voiding frequency (OR 7.40, CI 2.15–39.66), and urodynamic findings indicative of neurogenic lower urinary tract dysfunction. Expanded Disability Status Scale shows no correlation. Those parameters (except post-void residual) are also associated with reduced bladder compliance, as potential risk for kidney damage. Conclusion: Therefore, bladder diary and urinary tract infection rate should be routinely assessed to identify patients who require urodynamics. |
format | Online Article Text |
id | pubmed-8774871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87748712022-01-21 Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis Beck, Janina Jaekel, Anke Kirsten Zeller, Federico Leopoldo Kowollik, Michael Kurze, Ines Kaufmann, Albert Feneberg, Wolfgang Brandt, Anna Flachenecker, Peter Henze, Thomas Domurath, Burkhard Schmidt, Paul Vance, Will Nelson Goldschmidt, Franziska Kirschner-Hermanns, Ruth Klara Maria Knüpfer, Stephanie C. Diagnostics (Basel) Article Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective: We aimed to identify clinical parameters indicative of neurogenic lower urinary tract dysfunction in multiple sclerosis patients. Methods: 207 patients were prospectively assessed independent of the presence of lower urinary tract symptoms. We analyzed Expanded Disability Status Scale scores, uroflowmetry, post-void residual, rate of urinary tract infections, standardized voiding frequency, and voided volume in correlation with urodynamic findings. Results: We found a significant correlation between post-void residual (odds ratio (OR) 4.17, confidence interval (CI) 1.20–22.46), urinary tract infection rate (OR 3.91, CI 1.13–21.0), voided volume (OR 4.53, CI 1.85–11.99), increased standardized voiding frequency (OR 7.40, CI 2.15–39.66), and urodynamic findings indicative of neurogenic lower urinary tract dysfunction. Expanded Disability Status Scale shows no correlation. Those parameters (except post-void residual) are also associated with reduced bladder compliance, as potential risk for kidney damage. Conclusion: Therefore, bladder diary and urinary tract infection rate should be routinely assessed to identify patients who require urodynamics. MDPI 2022-01-13 /pmc/articles/PMC8774871/ /pubmed/35054358 http://dx.doi.org/10.3390/diagnostics12010191 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Beck, Janina Jaekel, Anke Kirsten Zeller, Federico Leopoldo Kowollik, Michael Kurze, Ines Kaufmann, Albert Feneberg, Wolfgang Brandt, Anna Flachenecker, Peter Henze, Thomas Domurath, Burkhard Schmidt, Paul Vance, Will Nelson Goldschmidt, Franziska Kirschner-Hermanns, Ruth Klara Maria Knüpfer, Stephanie C. Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title | Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title_full | Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title_fullStr | Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title_full_unstemmed | Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title_short | Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis |
title_sort | clinical predictors of neurogenic lower urinary tract dysfunction in persons with multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774871/ https://www.ncbi.nlm.nih.gov/pubmed/35054358 http://dx.doi.org/10.3390/diagnostics12010191 |
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