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Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis

Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective:...

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Autores principales: Beck, Janina, Jaekel, Anke Kirsten, Zeller, Federico Leopoldo, Kowollik, Michael, Kurze, Ines, Kaufmann, Albert, Feneberg, Wolfgang, Brandt, Anna, Flachenecker, Peter, Henze, Thomas, Domurath, Burkhard, Schmidt, Paul, Vance, Will Nelson, Goldschmidt, Franziska, Kirschner-Hermanns, Ruth Klara Maria, Knüpfer, Stephanie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774871/
https://www.ncbi.nlm.nih.gov/pubmed/35054358
http://dx.doi.org/10.3390/diagnostics12010191
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author Beck, Janina
Jaekel, Anke Kirsten
Zeller, Federico Leopoldo
Kowollik, Michael
Kurze, Ines
Kaufmann, Albert
Feneberg, Wolfgang
Brandt, Anna
Flachenecker, Peter
Henze, Thomas
Domurath, Burkhard
Schmidt, Paul
Vance, Will Nelson
Goldschmidt, Franziska
Kirschner-Hermanns, Ruth Klara Maria
Knüpfer, Stephanie C.
author_facet Beck, Janina
Jaekel, Anke Kirsten
Zeller, Federico Leopoldo
Kowollik, Michael
Kurze, Ines
Kaufmann, Albert
Feneberg, Wolfgang
Brandt, Anna
Flachenecker, Peter
Henze, Thomas
Domurath, Burkhard
Schmidt, Paul
Vance, Will Nelson
Goldschmidt, Franziska
Kirschner-Hermanns, Ruth Klara Maria
Knüpfer, Stephanie C.
author_sort Beck, Janina
collection PubMed
description Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective: We aimed to identify clinical parameters indicative of neurogenic lower urinary tract dysfunction in multiple sclerosis patients. Methods: 207 patients were prospectively assessed independent of the presence of lower urinary tract symptoms. We analyzed Expanded Disability Status Scale scores, uroflowmetry, post-void residual, rate of urinary tract infections, standardized voiding frequency, and voided volume in correlation with urodynamic findings. Results: We found a significant correlation between post-void residual (odds ratio (OR) 4.17, confidence interval (CI) 1.20–22.46), urinary tract infection rate (OR 3.91, CI 1.13–21.0), voided volume (OR 4.53, CI 1.85–11.99), increased standardized voiding frequency (OR 7.40, CI 2.15–39.66), and urodynamic findings indicative of neurogenic lower urinary tract dysfunction. Expanded Disability Status Scale shows no correlation. Those parameters (except post-void residual) are also associated with reduced bladder compliance, as potential risk for kidney damage. Conclusion: Therefore, bladder diary and urinary tract infection rate should be routinely assessed to identify patients who require urodynamics.
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spelling pubmed-87748712022-01-21 Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis Beck, Janina Jaekel, Anke Kirsten Zeller, Federico Leopoldo Kowollik, Michael Kurze, Ines Kaufmann, Albert Feneberg, Wolfgang Brandt, Anna Flachenecker, Peter Henze, Thomas Domurath, Burkhard Schmidt, Paul Vance, Will Nelson Goldschmidt, Franziska Kirschner-Hermanns, Ruth Klara Maria Knüpfer, Stephanie C. Diagnostics (Basel) Article Background: Multiple sclerosis patients often develop neurogenic lower urinary tract dysfunction with a potential risk of upper urinary tract damage. Diagnostic tools are urodynamics, bladder diary, uroflowmetry, and post-void residual, but recommendations for their use are controversial. Objective: We aimed to identify clinical parameters indicative of neurogenic lower urinary tract dysfunction in multiple sclerosis patients. Methods: 207 patients were prospectively assessed independent of the presence of lower urinary tract symptoms. We analyzed Expanded Disability Status Scale scores, uroflowmetry, post-void residual, rate of urinary tract infections, standardized voiding frequency, and voided volume in correlation with urodynamic findings. Results: We found a significant correlation between post-void residual (odds ratio (OR) 4.17, confidence interval (CI) 1.20–22.46), urinary tract infection rate (OR 3.91, CI 1.13–21.0), voided volume (OR 4.53, CI 1.85–11.99), increased standardized voiding frequency (OR 7.40, CI 2.15–39.66), and urodynamic findings indicative of neurogenic lower urinary tract dysfunction. Expanded Disability Status Scale shows no correlation. Those parameters (except post-void residual) are also associated with reduced bladder compliance, as potential risk for kidney damage. Conclusion: Therefore, bladder diary and urinary tract infection rate should be routinely assessed to identify patients who require urodynamics. MDPI 2022-01-13 /pmc/articles/PMC8774871/ /pubmed/35054358 http://dx.doi.org/10.3390/diagnostics12010191 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beck, Janina
Jaekel, Anke Kirsten
Zeller, Federico Leopoldo
Kowollik, Michael
Kurze, Ines
Kaufmann, Albert
Feneberg, Wolfgang
Brandt, Anna
Flachenecker, Peter
Henze, Thomas
Domurath, Burkhard
Schmidt, Paul
Vance, Will Nelson
Goldschmidt, Franziska
Kirschner-Hermanns, Ruth Klara Maria
Knüpfer, Stephanie C.
Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title_full Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title_fullStr Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title_full_unstemmed Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title_short Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with Multiple Sclerosis
title_sort clinical predictors of neurogenic lower urinary tract dysfunction in persons with multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774871/
https://www.ncbi.nlm.nih.gov/pubmed/35054358
http://dx.doi.org/10.3390/diagnostics12010191
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