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A Review on Secondary Immune Thrombocytopenia in Malaysia

Immune thrombocytopenia (ITP) is an acquired autoimmune disease that occurs in adults and children. In Malaysia, the clinical practice guideline (CPG) for the management of ITP was issued in 2006, which focused almost exclusively on primary ITP (pITP), and only a few secondary ITP (sITP) forms were...

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Autores principales: Zahidin, Muhamad Aidil, Mohd Noor, Noor Haslina, Johan, Muhammad Farid, Abdullah, Abu Dzarr, Zulkafli, Zefarina, Edinur, Hisham Atan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774929/
https://www.ncbi.nlm.nih.gov/pubmed/35052202
http://dx.doi.org/10.3390/healthcare10010038
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author Zahidin, Muhamad Aidil
Mohd Noor, Noor Haslina
Johan, Muhammad Farid
Abdullah, Abu Dzarr
Zulkafli, Zefarina
Edinur, Hisham Atan
author_facet Zahidin, Muhamad Aidil
Mohd Noor, Noor Haslina
Johan, Muhammad Farid
Abdullah, Abu Dzarr
Zulkafli, Zefarina
Edinur, Hisham Atan
author_sort Zahidin, Muhamad Aidil
collection PubMed
description Immune thrombocytopenia (ITP) is an acquired autoimmune disease that occurs in adults and children. In Malaysia, the clinical practice guideline (CPG) for the management of ITP was issued in 2006, which focused almost exclusively on primary ITP (pITP), and only a few secondary ITP (sITP) forms were addressed. All published (twenty-three) sITP articles among children and adults in Malaysia, identified on the academic databases were retrieved. The articles were published between 1981 and 2019, at a rate of 0.62 publications per year. The publications were considered low and mainly focused on rare presentation and followed-up of secondary diseases. This review revealed that sITP in Malaysia is commonly associated with autoimmune diseases (Evan’s syndrome, SLE and WAS), malignancy (Kaposi’s sarcoma and breast cancer) and infection (dengue haemorrhagic fever, Helicobacter pylori and hepatitis C virus). The relationship between ITP and autoimmune diseases, malignancy and infections raise the question concerning the mechanism involved in these associations. Further studies should be conducted to bridge the current knowledge gap, and the further information is required to update the existing CPG of management of ITP in Malaysia.
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spelling pubmed-87749292022-01-21 A Review on Secondary Immune Thrombocytopenia in Malaysia Zahidin, Muhamad Aidil Mohd Noor, Noor Haslina Johan, Muhammad Farid Abdullah, Abu Dzarr Zulkafli, Zefarina Edinur, Hisham Atan Healthcare (Basel) Review Immune thrombocytopenia (ITP) is an acquired autoimmune disease that occurs in adults and children. In Malaysia, the clinical practice guideline (CPG) for the management of ITP was issued in 2006, which focused almost exclusively on primary ITP (pITP), and only a few secondary ITP (sITP) forms were addressed. All published (twenty-three) sITP articles among children and adults in Malaysia, identified on the academic databases were retrieved. The articles were published between 1981 and 2019, at a rate of 0.62 publications per year. The publications were considered low and mainly focused on rare presentation and followed-up of secondary diseases. This review revealed that sITP in Malaysia is commonly associated with autoimmune diseases (Evan’s syndrome, SLE and WAS), malignancy (Kaposi’s sarcoma and breast cancer) and infection (dengue haemorrhagic fever, Helicobacter pylori and hepatitis C virus). The relationship between ITP and autoimmune diseases, malignancy and infections raise the question concerning the mechanism involved in these associations. Further studies should be conducted to bridge the current knowledge gap, and the further information is required to update the existing CPG of management of ITP in Malaysia. MDPI 2021-12-26 /pmc/articles/PMC8774929/ /pubmed/35052202 http://dx.doi.org/10.3390/healthcare10010038 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zahidin, Muhamad Aidil
Mohd Noor, Noor Haslina
Johan, Muhammad Farid
Abdullah, Abu Dzarr
Zulkafli, Zefarina
Edinur, Hisham Atan
A Review on Secondary Immune Thrombocytopenia in Malaysia
title A Review on Secondary Immune Thrombocytopenia in Malaysia
title_full A Review on Secondary Immune Thrombocytopenia in Malaysia
title_fullStr A Review on Secondary Immune Thrombocytopenia in Malaysia
title_full_unstemmed A Review on Secondary Immune Thrombocytopenia in Malaysia
title_short A Review on Secondary Immune Thrombocytopenia in Malaysia
title_sort review on secondary immune thrombocytopenia in malaysia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774929/
https://www.ncbi.nlm.nih.gov/pubmed/35052202
http://dx.doi.org/10.3390/healthcare10010038
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