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Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-pos...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774933/ https://www.ncbi.nlm.nih.gov/pubmed/35054389 http://dx.doi.org/10.3390/diagnostics12010222 |
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author | Han, Eun Ji O, Joo Hyun Yoon, Hyukjin Ha, Seunggyun Yoo, Ie Ryung Min, Jae Won Choi, Joon-Il Choi, Byung-Ock Park, Gyeongsin Lee, Han Hee Jeon, Young-Woo Min, Gi-June Cho, Seok-Goo |
author_facet | Han, Eun Ji O, Joo Hyun Yoon, Hyukjin Ha, Seunggyun Yoo, Ie Ryung Min, Jae Won Choi, Joon-Il Choi, Byung-Ock Park, Gyeongsin Lee, Han Hee Jeon, Young-Woo Min, Gi-June Cho, Seok-Goo |
author_sort | Han, Eun Ji |
collection | PubMed |
description | Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-positive for bone lesions on visual assessment. A fair degree of agreement was present between PET and BMBx findings (ĸ = 0.362, p < 0.001). Bone involvement on PET/CT lead to stage IV in 12 patients, despite no other evidence of extranodal lesion. Of 35 discordant PET-positive and BMBx-negative cases, 22 (63%) had discrete bone uptake on PET/CT. A total of 144 patients were eligible for radiomic analysis, and two grey-level zone-length matrix derived parameters obtained from the iliac crests showed a trend for higher values in the BMBx-positive group compared to the BMBx-negative group (mean 436.6 ± 449.0 versus 227.2 ± 137.8, unadjusted p = 0.037 for high grey-level zone emphasis; mean 308.8 ± 394.4 versus 135.7 ± 97.2, unadjusted p = 0.048 for short-zone high grey-level emphasis), but statistical significance was not found after multiple comparison correction. Visual FDG PET/CT assessment and BMBx results were discordant in 17% of patients with newly diagnosed DLBCL, and the two tests are complementary in the evaluation of bone involvement. |
format | Online Article Text |
id | pubmed-8774933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87749332022-01-21 Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics Han, Eun Ji O, Joo Hyun Yoon, Hyukjin Ha, Seunggyun Yoo, Ie Ryung Min, Jae Won Choi, Joon-Il Choi, Byung-Ock Park, Gyeongsin Lee, Han Hee Jeon, Young-Woo Min, Gi-June Cho, Seok-Goo Diagnostics (Basel) Article Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-positive for bone lesions on visual assessment. A fair degree of agreement was present between PET and BMBx findings (ĸ = 0.362, p < 0.001). Bone involvement on PET/CT lead to stage IV in 12 patients, despite no other evidence of extranodal lesion. Of 35 discordant PET-positive and BMBx-negative cases, 22 (63%) had discrete bone uptake on PET/CT. A total of 144 patients were eligible for radiomic analysis, and two grey-level zone-length matrix derived parameters obtained from the iliac crests showed a trend for higher values in the BMBx-positive group compared to the BMBx-negative group (mean 436.6 ± 449.0 versus 227.2 ± 137.8, unadjusted p = 0.037 for high grey-level zone emphasis; mean 308.8 ± 394.4 versus 135.7 ± 97.2, unadjusted p = 0.048 for short-zone high grey-level emphasis), but statistical significance was not found after multiple comparison correction. Visual FDG PET/CT assessment and BMBx results were discordant in 17% of patients with newly diagnosed DLBCL, and the two tests are complementary in the evaluation of bone involvement. MDPI 2022-01-17 /pmc/articles/PMC8774933/ /pubmed/35054389 http://dx.doi.org/10.3390/diagnostics12010222 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Han, Eun Ji O, Joo Hyun Yoon, Hyukjin Ha, Seunggyun Yoo, Ie Ryung Min, Jae Won Choi, Joon-Il Choi, Byung-Ock Park, Gyeongsin Lee, Han Hee Jeon, Young-Woo Min, Gi-June Cho, Seok-Goo Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title | Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title_full | Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title_fullStr | Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title_full_unstemmed | Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title_short | Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics |
title_sort | comparison of fdg pet/ct and bone marrow biopsy results in patients with diffuse large b cell lymphoma with subgroup analysis of pet radiomics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774933/ https://www.ncbi.nlm.nih.gov/pubmed/35054389 http://dx.doi.org/10.3390/diagnostics12010222 |
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