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Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics

Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-pos...

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Autores principales: Han, Eun Ji, O, Joo Hyun, Yoon, Hyukjin, Ha, Seunggyun, Yoo, Ie Ryung, Min, Jae Won, Choi, Joon-Il, Choi, Byung-Ock, Park, Gyeongsin, Lee, Han Hee, Jeon, Young-Woo, Min, Gi-June, Cho, Seok-Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774933/
https://www.ncbi.nlm.nih.gov/pubmed/35054389
http://dx.doi.org/10.3390/diagnostics12010222
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author Han, Eun Ji
O, Joo Hyun
Yoon, Hyukjin
Ha, Seunggyun
Yoo, Ie Ryung
Min, Jae Won
Choi, Joon-Il
Choi, Byung-Ock
Park, Gyeongsin
Lee, Han Hee
Jeon, Young-Woo
Min, Gi-June
Cho, Seok-Goo
author_facet Han, Eun Ji
O, Joo Hyun
Yoon, Hyukjin
Ha, Seunggyun
Yoo, Ie Ryung
Min, Jae Won
Choi, Joon-Il
Choi, Byung-Ock
Park, Gyeongsin
Lee, Han Hee
Jeon, Young-Woo
Min, Gi-June
Cho, Seok-Goo
author_sort Han, Eun Ji
collection PubMed
description Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-positive for bone lesions on visual assessment. A fair degree of agreement was present between PET and BMBx findings (ĸ = 0.362, p < 0.001). Bone involvement on PET/CT lead to stage IV in 12 patients, despite no other evidence of extranodal lesion. Of 35 discordant PET-positive and BMBx-negative cases, 22 (63%) had discrete bone uptake on PET/CT. A total of 144 patients were eligible for radiomic analysis, and two grey-level zone-length matrix derived parameters obtained from the iliac crests showed a trend for higher values in the BMBx-positive group compared to the BMBx-negative group (mean 436.6 ± 449.0 versus 227.2 ± 137.8, unadjusted p = 0.037 for high grey-level zone emphasis; mean 308.8 ± 394.4 versus 135.7 ± 97.2, unadjusted p = 0.048 for short-zone high grey-level emphasis), but statistical significance was not found after multiple comparison correction. Visual FDG PET/CT assessment and BMBx results were discordant in 17% of patients with newly diagnosed DLBCL, and the two tests are complementary in the evaluation of bone involvement.
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spelling pubmed-87749332022-01-21 Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics Han, Eun Ji O, Joo Hyun Yoon, Hyukjin Ha, Seunggyun Yoo, Ie Ryung Min, Jae Won Choi, Joon-Il Choi, Byung-Ock Park, Gyeongsin Lee, Han Hee Jeon, Young-Woo Min, Gi-June Cho, Seok-Goo Diagnostics (Basel) Article Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-positive for bone lesions on visual assessment. A fair degree of agreement was present between PET and BMBx findings (ĸ = 0.362, p < 0.001). Bone involvement on PET/CT lead to stage IV in 12 patients, despite no other evidence of extranodal lesion. Of 35 discordant PET-positive and BMBx-negative cases, 22 (63%) had discrete bone uptake on PET/CT. A total of 144 patients were eligible for radiomic analysis, and two grey-level zone-length matrix derived parameters obtained from the iliac crests showed a trend for higher values in the BMBx-positive group compared to the BMBx-negative group (mean 436.6 ± 449.0 versus 227.2 ± 137.8, unadjusted p = 0.037 for high grey-level zone emphasis; mean 308.8 ± 394.4 versus 135.7 ± 97.2, unadjusted p = 0.048 for short-zone high grey-level emphasis), but statistical significance was not found after multiple comparison correction. Visual FDG PET/CT assessment and BMBx results were discordant in 17% of patients with newly diagnosed DLBCL, and the two tests are complementary in the evaluation of bone involvement. MDPI 2022-01-17 /pmc/articles/PMC8774933/ /pubmed/35054389 http://dx.doi.org/10.3390/diagnostics12010222 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Eun Ji
O, Joo Hyun
Yoon, Hyukjin
Ha, Seunggyun
Yoo, Ie Ryung
Min, Jae Won
Choi, Joon-Il
Choi, Byung-Ock
Park, Gyeongsin
Lee, Han Hee
Jeon, Young-Woo
Min, Gi-June
Cho, Seok-Goo
Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title_full Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title_fullStr Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title_full_unstemmed Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title_short Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics
title_sort comparison of fdg pet/ct and bone marrow biopsy results in patients with diffuse large b cell lymphoma with subgroup analysis of pet radiomics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774933/
https://www.ncbi.nlm.nih.gov/pubmed/35054389
http://dx.doi.org/10.3390/diagnostics12010222
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