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Clinical characteristics and histopathology of COVID-19 related deaths in South African adults

Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a pos...

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Autores principales: Nunes, Marta C., Hale, Martin J., Mahtab, Sana, Mabena, Fikile C., Dludlu, Noluthando, Baillie, Vicky L., Thwala, Bukiwe N., Els, Toyah, du Plessis, Jeanine, Laubscher, Marius, Mckenzie, Shakeel, Mtshali, Sihle, Menezes, Colin, Serafin, Natali, van Blydenstein, Sarah, Tsitsi, Merika, Dulisse, Brian, Madhi, Shabir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775212/
https://www.ncbi.nlm.nih.gov/pubmed/35051205
http://dx.doi.org/10.1371/journal.pone.0262179
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author Nunes, Marta C.
Hale, Martin J.
Mahtab, Sana
Mabena, Fikile C.
Dludlu, Noluthando
Baillie, Vicky L.
Thwala, Bukiwe N.
Els, Toyah
du Plessis, Jeanine
Laubscher, Marius
Mckenzie, Shakeel
Mtshali, Sihle
Menezes, Colin
Serafin, Natali
van Blydenstein, Sarah
Tsitsi, Merika
Dulisse, Brian
Madhi, Shabir A.
author_facet Nunes, Marta C.
Hale, Martin J.
Mahtab, Sana
Mabena, Fikile C.
Dludlu, Noluthando
Baillie, Vicky L.
Thwala, Bukiwe N.
Els, Toyah
du Plessis, Jeanine
Laubscher, Marius
Mckenzie, Shakeel
Mtshali, Sihle
Menezes, Colin
Serafin, Natali
van Blydenstein, Sarah
Tsitsi, Merika
Dulisse, Brian
Madhi, Shabir A.
author_sort Nunes, Marta C.
collection PubMed
description Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a positive ante-mortem SARS-CoV-2 PCR test and/or respiratory disease symptoms at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa from 15th April to 2nd November 2020, during the first wave of the South African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed to investigate for SARS-CoV-2 infection and molecular detection of putative pathogens on blood and lung samples, and histopathology examination of lung, liver and heart tissue. During the study period MITS were done in patients displaying symptoms of respiratory disease including 75 COVID-19-related deaths (COVID+) and 42 non-COVID-19-related deaths (COVID-). The prevalence of HIV-infection was lower in COVID+ (27%) than in the COVID- (64%), MTB detection was also less common among COVID+ (3% vs 13%). Lung histopathology findings showed differences between COVID+ and COVID- in the severity of the morphological appearance of Type-II pneumocytes, alveolar injury and repair initiated by SARS-CoV-2 infection. In the liver necrotising granulomatous inflammation was more common among COVID+. No differences were found in heart analyses. The prevalence of bacterial co-infections was higher in COVID+. Most indicators of respiratory distress syndrome were undifferentiated between COVID+ and COVID- except for Type-II pneumocytes. HIV or MTB infection does not appear in these data to have a meaningful correspondence with COVID-related deaths.
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spelling pubmed-87752122022-01-21 Clinical characteristics and histopathology of COVID-19 related deaths in South African adults Nunes, Marta C. Hale, Martin J. Mahtab, Sana Mabena, Fikile C. Dludlu, Noluthando Baillie, Vicky L. Thwala, Bukiwe N. Els, Toyah du Plessis, Jeanine Laubscher, Marius Mckenzie, Shakeel Mtshali, Sihle Menezes, Colin Serafin, Natali van Blydenstein, Sarah Tsitsi, Merika Dulisse, Brian Madhi, Shabir A. PLoS One Research Article Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a positive ante-mortem SARS-CoV-2 PCR test and/or respiratory disease symptoms at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa from 15th April to 2nd November 2020, during the first wave of the South African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed to investigate for SARS-CoV-2 infection and molecular detection of putative pathogens on blood and lung samples, and histopathology examination of lung, liver and heart tissue. During the study period MITS were done in patients displaying symptoms of respiratory disease including 75 COVID-19-related deaths (COVID+) and 42 non-COVID-19-related deaths (COVID-). The prevalence of HIV-infection was lower in COVID+ (27%) than in the COVID- (64%), MTB detection was also less common among COVID+ (3% vs 13%). Lung histopathology findings showed differences between COVID+ and COVID- in the severity of the morphological appearance of Type-II pneumocytes, alveolar injury and repair initiated by SARS-CoV-2 infection. In the liver necrotising granulomatous inflammation was more common among COVID+. No differences were found in heart analyses. The prevalence of bacterial co-infections was higher in COVID+. Most indicators of respiratory distress syndrome were undifferentiated between COVID+ and COVID- except for Type-II pneumocytes. HIV or MTB infection does not appear in these data to have a meaningful correspondence with COVID-related deaths. Public Library of Science 2022-01-20 /pmc/articles/PMC8775212/ /pubmed/35051205 http://dx.doi.org/10.1371/journal.pone.0262179 Text en © 2022 Nunes et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nunes, Marta C.
Hale, Martin J.
Mahtab, Sana
Mabena, Fikile C.
Dludlu, Noluthando
Baillie, Vicky L.
Thwala, Bukiwe N.
Els, Toyah
du Plessis, Jeanine
Laubscher, Marius
Mckenzie, Shakeel
Mtshali, Sihle
Menezes, Colin
Serafin, Natali
van Blydenstein, Sarah
Tsitsi, Merika
Dulisse, Brian
Madhi, Shabir A.
Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title_full Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title_fullStr Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title_full_unstemmed Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title_short Clinical characteristics and histopathology of COVID-19 related deaths in South African adults
title_sort clinical characteristics and histopathology of covid-19 related deaths in south african adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775212/
https://www.ncbi.nlm.nih.gov/pubmed/35051205
http://dx.doi.org/10.1371/journal.pone.0262179
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