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Causal Association between Periodontal Diseases and Cardiovascular Diseases
Observational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775300/ https://www.ncbi.nlm.nih.gov/pubmed/35052354 http://dx.doi.org/10.3390/genes13010013 |
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author | Zhou, Mengchen Dong, Jiangtao Zha, Lingfeng Liao, Yuhua |
author_facet | Zhou, Mengchen Dong, Jiangtao Zha, Lingfeng Liao, Yuhua |
author_sort | Zhou, Mengchen |
collection | PubMed |
description | Observational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR) studies were carried out to assess the association between genetic liability for periodontal diseases (dental caries and periodontitis) and major CVDs, including coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke—including ischemic stroke as well as its three main subtypes—based on large-scale genome-wide association studies (GWASs). Our two-sample MR analyses did not provide evidence for dental caries and periodontitis as the causes of cardiovascular diseases; sensitivity analyses, including MR–Egger analysis and weighted median analysis, also supported this result. Gene functional annotation and pathway enrichment analyses indicated the common pathophysiology between cardiovascular diseases and periodontal diseases. The associations from observational studies may be explained by shared risk factors and comorbidities instead of direct consequences. This also suggests that addressing the common risk factors—such as reducing obesity and improving glucose tolerance—could benefit both conditions. |
format | Online Article Text |
id | pubmed-8775300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87753002022-01-21 Causal Association between Periodontal Diseases and Cardiovascular Diseases Zhou, Mengchen Dong, Jiangtao Zha, Lingfeng Liao, Yuhua Genes (Basel) Article Observational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR) studies were carried out to assess the association between genetic liability for periodontal diseases (dental caries and periodontitis) and major CVDs, including coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke—including ischemic stroke as well as its three main subtypes—based on large-scale genome-wide association studies (GWASs). Our two-sample MR analyses did not provide evidence for dental caries and periodontitis as the causes of cardiovascular diseases; sensitivity analyses, including MR–Egger analysis and weighted median analysis, also supported this result. Gene functional annotation and pathway enrichment analyses indicated the common pathophysiology between cardiovascular diseases and periodontal diseases. The associations from observational studies may be explained by shared risk factors and comorbidities instead of direct consequences. This also suggests that addressing the common risk factors—such as reducing obesity and improving glucose tolerance—could benefit both conditions. MDPI 2021-12-22 /pmc/articles/PMC8775300/ /pubmed/35052354 http://dx.doi.org/10.3390/genes13010013 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Mengchen Dong, Jiangtao Zha, Lingfeng Liao, Yuhua Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title_full | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title_fullStr | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title_full_unstemmed | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title_short | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
title_sort | causal association between periodontal diseases and cardiovascular diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775300/ https://www.ncbi.nlm.nih.gov/pubmed/35052354 http://dx.doi.org/10.3390/genes13010013 |
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