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Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

The assessment of human papillomavirus (HPV) genotype dynamics could support the adoption of more tailored preventive actions against cervical cancer. The aim of the study was to describe the prevalence of HPV infection, HPV genotype distribution, and the epidemiological characteristics of women wit...

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Autores principales: Muresu, Narcisa, Sotgiu, Giovanni, Marras, Silvia, Gentili, Davide, Sechi, Illari, Cossu, Andrea, Dettori, Arianna, Pietri, Roberto Enrico, Paoni, Luisa, Ghi, Maria Eugenia, Bagella, Maria Paola, Marrazzu, Adriano, Cossu, Antonio, Genovesi, Antonio, Piana, Andrea, Saderi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775344/
https://www.ncbi.nlm.nih.gov/pubmed/35055515
http://dx.doi.org/10.3390/ijerph19020693
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author Muresu, Narcisa
Sotgiu, Giovanni
Marras, Silvia
Gentili, Davide
Sechi, Illari
Cossu, Andrea
Dettori, Arianna
Pietri, Roberto Enrico
Paoni, Luisa
Ghi, Maria Eugenia
Bagella, Maria Paola
Marrazzu, Adriano
Cossu, Antonio
Genovesi, Antonio
Piana, Andrea
Saderi, Laura
author_facet Muresu, Narcisa
Sotgiu, Giovanni
Marras, Silvia
Gentili, Davide
Sechi, Illari
Cossu, Andrea
Dettori, Arianna
Pietri, Roberto Enrico
Paoni, Luisa
Ghi, Maria Eugenia
Bagella, Maria Paola
Marrazzu, Adriano
Cossu, Antonio
Genovesi, Antonio
Piana, Andrea
Saderi, Laura
author_sort Muresu, Narcisa
collection PubMed
description The assessment of human papillomavirus (HPV) genotype dynamics could support the adoption of more tailored preventive actions against cervical cancer. The aim of the study was to describe the prevalence of HPV infection, HPV genotype distribution, and the epidemiological characteristics of women with ASC-US cytology since the introduction of HPV-DNA testing in Sardinia (Italy), (March 2016–December 2020). Specimens were tested by RT-PCR for 14 high-risk HPV genotypes. A total of 1186 patients were enrolled, with a median (IQR) age of 41 (38–48) years. Of these women, 48.1% were positive for at least one HPV genotype; 311 (26.2%) women were vaccinated with a median (IQR) age of 38 (30/47) years. The percentage of prevalence of HPV-16, -31, -66, -56, and -51 was 36.3%, 18.7%, 11.9%, 11.4% and 10.7%, respectively. The highest prevalence of infection was found in women aged <41 years, and single women. Moreover, women aged >41 years (OR: 0.51, 95% CI: 0.31–0.86; p-value: 0.01), having parity (OR: 0.57, 95% CI: 0.34–0.96, p-value: 0.04), and higher educational level (OR: 0.39, 95% CI: 0.18–0.87; p-value: 0.02) were associated with a lower CIN2+ risk. We did not find a significant difference in terms of prevalence of HPV-16 infection between vaccinated and non-vaccinated (18.3% vs. 17.1%; p-value < 0.001). Our results support the adoption of nonavalent HPV-vaccine to prevent the most prevalent infections caused by HPV-16 and -31 genotypes and underscore the need of surveillance to implement tailored vaccination programs and preventive strategies.
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spelling pubmed-87753442022-01-21 Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology Muresu, Narcisa Sotgiu, Giovanni Marras, Silvia Gentili, Davide Sechi, Illari Cossu, Andrea Dettori, Arianna Pietri, Roberto Enrico Paoni, Luisa Ghi, Maria Eugenia Bagella, Maria Paola Marrazzu, Adriano Cossu, Antonio Genovesi, Antonio Piana, Andrea Saderi, Laura Int J Environ Res Public Health Article The assessment of human papillomavirus (HPV) genotype dynamics could support the adoption of more tailored preventive actions against cervical cancer. The aim of the study was to describe the prevalence of HPV infection, HPV genotype distribution, and the epidemiological characteristics of women with ASC-US cytology since the introduction of HPV-DNA testing in Sardinia (Italy), (March 2016–December 2020). Specimens were tested by RT-PCR for 14 high-risk HPV genotypes. A total of 1186 patients were enrolled, with a median (IQR) age of 41 (38–48) years. Of these women, 48.1% were positive for at least one HPV genotype; 311 (26.2%) women were vaccinated with a median (IQR) age of 38 (30/47) years. The percentage of prevalence of HPV-16, -31, -66, -56, and -51 was 36.3%, 18.7%, 11.9%, 11.4% and 10.7%, respectively. The highest prevalence of infection was found in women aged <41 years, and single women. Moreover, women aged >41 years (OR: 0.51, 95% CI: 0.31–0.86; p-value: 0.01), having parity (OR: 0.57, 95% CI: 0.34–0.96, p-value: 0.04), and higher educational level (OR: 0.39, 95% CI: 0.18–0.87; p-value: 0.02) were associated with a lower CIN2+ risk. We did not find a significant difference in terms of prevalence of HPV-16 infection between vaccinated and non-vaccinated (18.3% vs. 17.1%; p-value < 0.001). Our results support the adoption of nonavalent HPV-vaccine to prevent the most prevalent infections caused by HPV-16 and -31 genotypes and underscore the need of surveillance to implement tailored vaccination programs and preventive strategies. MDPI 2022-01-08 /pmc/articles/PMC8775344/ /pubmed/35055515 http://dx.doi.org/10.3390/ijerph19020693 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muresu, Narcisa
Sotgiu, Giovanni
Marras, Silvia
Gentili, Davide
Sechi, Illari
Cossu, Andrea
Dettori, Arianna
Pietri, Roberto Enrico
Paoni, Luisa
Ghi, Maria Eugenia
Bagella, Maria Paola
Marrazzu, Adriano
Cossu, Antonio
Genovesi, Antonio
Piana, Andrea
Saderi, Laura
Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title_full Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title_fullStr Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title_full_unstemmed Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title_short Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
title_sort cervical screening in north sardinia (italy): genotype distribution and prevalence of hpv among women with asc-us cytology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775344/
https://www.ncbi.nlm.nih.gov/pubmed/35055515
http://dx.doi.org/10.3390/ijerph19020693
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