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Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry

Background: Currently, diabetes represents the seventh leading cause of death worldwide, with a significant economic burden. The number and severity of comorbidities increase with age, and are identified as important determinants that influence the prognosis. We aimed to investigate comorbidities an...

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Autores principales: Argano, Christiano, Natoli, Giuseppe, Mularo, Salvatore, Nobili, Alessandro, Monaco, Marika Lo, Mannucci, Pier Mannuccio, Perticone, Francesco, Pietrangelo, Antonello, Corrao, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775367/
https://www.ncbi.nlm.nih.gov/pubmed/35052252
http://dx.doi.org/10.3390/healthcare10010086
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author Argano, Christiano
Natoli, Giuseppe
Mularo, Salvatore
Nobili, Alessandro
Monaco, Marika Lo
Mannucci, Pier Mannuccio
Perticone, Francesco
Pietrangelo, Antonello
Corrao, Salvatore
author_facet Argano, Christiano
Natoli, Giuseppe
Mularo, Salvatore
Nobili, Alessandro
Monaco, Marika Lo
Mannucci, Pier Mannuccio
Perticone, Francesco
Pietrangelo, Antonello
Corrao, Salvatore
author_sort Argano, Christiano
collection PubMed
description Background: Currently, diabetes represents the seventh leading cause of death worldwide, with a significant economic burden. The number and severity of comorbidities increase with age, and are identified as important determinants that influence the prognosis. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients affected by diabetes. Methods: In this observational study, we retrospectively analyzed data collected from the REgistro dei pazienti per lo studio delle POlipatologie e politerapie in reparti della rete Simi (RePoSi) registry. Socio-demographic, clinical characteristics, and laboratory findings were considered. The association between variables and in-hospital and 1-year follow-up were analyzed. Results: Among 4708 in-patients, 1378 (29.3%) had a diagnosis of diabetes. Patients with diabetes had more previous hospitalization, a clinically significant disability, and more need for a urinary catheter in comparison with subjects without diabetes. Patients affected by diabetes took more drugs, both at admission, at in-hospital stay, at discharge, and at 1-year follow-up. Thirty-five comorbidities were more frequent in patients with diabetes, and the first five were hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and chronic obstructive pulmonary disease (22.7%). Heart rate was an independent predictor of in-hospital mortality. At 1-year follow-up, cancer and male sex were strongly independently associated with mortality. Conclusions: Our findings showed the severity of the impact of diabetes and its comorbidities in the real life of internal medicine and geriatric wards, and provide data to be used for a better tailored management of elderly in-patients with diabetes.
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spelling pubmed-87753672022-01-21 Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry Argano, Christiano Natoli, Giuseppe Mularo, Salvatore Nobili, Alessandro Monaco, Marika Lo Mannucci, Pier Mannuccio Perticone, Francesco Pietrangelo, Antonello Corrao, Salvatore Healthcare (Basel) Article Background: Currently, diabetes represents the seventh leading cause of death worldwide, with a significant economic burden. The number and severity of comorbidities increase with age, and are identified as important determinants that influence the prognosis. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients affected by diabetes. Methods: In this observational study, we retrospectively analyzed data collected from the REgistro dei pazienti per lo studio delle POlipatologie e politerapie in reparti della rete Simi (RePoSi) registry. Socio-demographic, clinical characteristics, and laboratory findings were considered. The association between variables and in-hospital and 1-year follow-up were analyzed. Results: Among 4708 in-patients, 1378 (29.3%) had a diagnosis of diabetes. Patients with diabetes had more previous hospitalization, a clinically significant disability, and more need for a urinary catheter in comparison with subjects without diabetes. Patients affected by diabetes took more drugs, both at admission, at in-hospital stay, at discharge, and at 1-year follow-up. Thirty-five comorbidities were more frequent in patients with diabetes, and the first five were hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and chronic obstructive pulmonary disease (22.7%). Heart rate was an independent predictor of in-hospital mortality. At 1-year follow-up, cancer and male sex were strongly independently associated with mortality. Conclusions: Our findings showed the severity of the impact of diabetes and its comorbidities in the real life of internal medicine and geriatric wards, and provide data to be used for a better tailored management of elderly in-patients with diabetes. MDPI 2022-01-03 /pmc/articles/PMC8775367/ /pubmed/35052252 http://dx.doi.org/10.3390/healthcare10010086 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Argano, Christiano
Natoli, Giuseppe
Mularo, Salvatore
Nobili, Alessandro
Monaco, Marika Lo
Mannucci, Pier Mannuccio
Perticone, Francesco
Pietrangelo, Antonello
Corrao, Salvatore
Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title_full Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title_fullStr Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title_full_unstemmed Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title_short Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry
title_sort impact of diabetes mellitus and its comorbidities on elderly patients hospitalized in internal medicine wards: data from the reposi registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775367/
https://www.ncbi.nlm.nih.gov/pubmed/35052252
http://dx.doi.org/10.3390/healthcare10010086
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