DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus

Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disease mediated by a toxic gain of function of mutant RNAs. The neuropsychological manifestations affect multiple domains of cognition and behavior, but their etiology remains elusive. Transgenic DMSXL mice carry the DM1 mutation, show behav...

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Detalles Bibliográficos
Autores principales: Potier, Brigitte, Lallemant, Louison, Parrot, Sandrine, Huguet-Lachon, Aline, Gourdon, Geneviève, Dutar, Patrick, Gomes-Pereira, Mário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775431/
https://www.ncbi.nlm.nih.gov/pubmed/35054778
http://dx.doi.org/10.3390/ijms23020592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775431/
https://www.ncbi.nlm.nih.gov/pubmed/35054778
http://dx.doi.org/10.3390/ijms23020592

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