Cargando…

DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus

Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disease mediated by a toxic gain of function of mutant RNAs. The neuropsychological manifestations affect multiple domains of cognition and behavior, but their etiology remains elusive. Transgenic DMSXL mice carry the DM1 mutation, show behav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potier, Brigitte, Lallemant, Louison, Parrot, Sandrine, Huguet-Lachon, Aline, Gourdon, Geneviève, Dutar, Patrick, Gomes-Pereira, Mário
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775431/ https://www.ncbi.nlm.nih.gov/pubmed/35054778 http://dx.doi.org/10.3390/ijms23020592

Ejemplares similares

Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development
por: Michel, Lise, et al.
Publicado: (2015)

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1
por: González-Barriga, Anchel, et al.
Publicado: (2021)

Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice
por: Lo Scrudato, Mirella, et al.
Publicado: (2019)

Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus
por: Brouwer, Judith Rixt, et al.
Publicado: (2013)

Molecular mechanisms in DM1 — a focus on foci
por: Pettersson, Olof Joakim, et al.
Publicado: (2015)

DM1 Phenotype Variability and Triplet Repeat Instability: Challenges in the Development of New Therapies
por: Tomé, Stéphanie, et al.
Publicado: (2020)

Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes
por: Dincã, Diana M., et al.
Publicado: (2022)

Author Correction: Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes
por: Dincã, Diana M., et al.
Publicado: (2022)

Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
por: Dansithong, Warunee, et al.
Publicado: (2008)

Comparison of different clearing and acquisition methods for 3D imaging of murine intestinal organoids
por: Lallemant, Louison, et al.
Publicado: (2020)

Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice
por: Alfaro-Ruiz, Rocio, et al.
Publicado: (2022)

Synaptic protein dysregulation in myotonic dystrophy type 1: Disease neuropathogenesis beyond missplicing
por: Hernández-Hernández, Oscar, et al.
Publicado: (2013)

Omics Profiles of Non-transgenic Scion Grafted on Transgenic RdDM Rootstock
por: Kodama, Hiroaki, et al.
Publicado: (2022)

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice
por: Alfaro‐Ruiz, Rocío, et al.
Publicado: (2022)

Neurotransmitter uptake of synaptic vesicles studied by X-ray diffraction
por: Komorowski, Karlo, et al.
Publicado: (2022)

Impact of Synaptic Neurotransmitter Concentration Time Course on the Kinetics and Pharmacological Modulation of Inhibitory Synaptic Currents
por: Barberis, Andrea, et al.
Publicado: (2011)

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy
por: Hu, Jiaxin, et al.
Publicado: (2018)

Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation
por: Festerling, Karina, et al.
Publicado: (2020)

A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction
por: Barreda, Jorge L, et al.
Publicado: (2011)

Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases
por: Wei, Ziqing, et al.
Publicado: (2022)

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release
por: Ramsay, Harrison J., et al.
Publicado: (2023)

Corticosteroid Regulation of Synaptic Plasticity in the Hippocampus
por: Maggio, Nicola, et al.
Publicado: (2010)

Molecular, Physiological, and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus
por: Huguet, Aline, et al.
Publicado: (2012)

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory
por: Marciniak, Elodie, et al.
Publicado: (2015)

Serotonin Discharge Regulation by Additional Neurotransmitters of Rat Hippocampus Associated With the Continence Central Circuit
por: Kim, Jae Heon, et al.
Publicado: (2021)

Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
por: Zhao, Ling, et al.
Publicado: (2023)

CPEB4 Knockout Mice Exhibit Normal Hippocampus-Related Synaptic Plasticity and Memory
por: Tsai, Li-Yun, et al.
Publicado: (2013)

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
por: Maximov, Anton, et al.
Publicado: (2007)

Neurotransmitter Secretion along Growing Nerve Processes: Comparison with Synaptic Vesicle Exocytosis
por: Zakharenko, Stanislav, et al.
Publicado: (1999)

Involvement of β-adrenergic receptor in synaptic vesicle swelling and implication in neurotransmitter release
por: Chen, Zhi Hui, et al.
Publicado: (2011)

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release
por: Bruckner, Joseph J., et al.
Publicado: (2017)

Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release
por: Bouazza-Arostegui, Boris, et al.
Publicado: (2022)

The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion
por: Wu, Shanshan, et al.
Publicado: (2023)

Erratum: AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release
Publicado: (2023)

Developmental Perchlorate Exposure and Synaptic Transmission in Hippocampus
por: Mavis, Richard D., et al.
Publicado: (2009)

A synaptic signal for novelty processing in the hippocampus
por: Gómez-Ocádiz, Ruy, et al.
Publicado: (2022)

COVID-19 and MIS-C treatment in children—results from an international survey
por: Donà, Daniele, et al.
Publicado: (2023)

Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters’ Tissue Content in Rats’ Hippocampus and Amygdala
por: Hammad, Alaa M., et al.
Publicado: (2023)

Functional and histopathological identification of the respiratory failure in a DMSXL transgenic mouse model of myotonic dystrophy
por: Panaite, Petrica-Adrian, et al.
Publicado: (2013)

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus
por: Khalilov, Ilgam, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_n70bu5dtg810skcmoqhg2cr150