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Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic suscept...

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Autores principales: Mertowska, Paulina, Mertowski, Sebastian, Smarz-Widelska, Iwona, Grywalska, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775480/
https://www.ncbi.nlm.nih.gov/pubmed/35054831
http://dx.doi.org/10.3390/ijms23020647
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author Mertowska, Paulina
Mertowski, Sebastian
Smarz-Widelska, Iwona
Grywalska, Ewelina
author_facet Mertowska, Paulina
Mertowski, Sebastian
Smarz-Widelska, Iwona
Grywalska, Ewelina
author_sort Mertowska, Paulina
collection PubMed
description Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic susceptibility, infections, immune disorders or high blood pressure is suggested. Difficulties in making a correct and quick diagnosis are caused by the lack of research on early molecular markers, as well as educational and preventive activities among the public, which leads to the late detection of kidney diseases. An important role in the homeostasis and disease progression, including kidney diseases, is attributed to interleukins, which perform several biological functions and interact with other cells and tissues of the body. The aim of this article was to systematize the knowledge about the biological functions performed by interleukins in humans and their involvement in kidney diseases development. In our work, we took into account the role of interleukins in acute and chronic kidney disease and kidney transplantation.
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spelling pubmed-87754802022-01-21 Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases Mertowska, Paulina Mertowski, Sebastian Smarz-Widelska, Iwona Grywalska, Ewelina Int J Mol Sci Review Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic susceptibility, infections, immune disorders or high blood pressure is suggested. Difficulties in making a correct and quick diagnosis are caused by the lack of research on early molecular markers, as well as educational and preventive activities among the public, which leads to the late detection of kidney diseases. An important role in the homeostasis and disease progression, including kidney diseases, is attributed to interleukins, which perform several biological functions and interact with other cells and tissues of the body. The aim of this article was to systematize the knowledge about the biological functions performed by interleukins in humans and their involvement in kidney diseases development. In our work, we took into account the role of interleukins in acute and chronic kidney disease and kidney transplantation. MDPI 2022-01-07 /pmc/articles/PMC8775480/ /pubmed/35054831 http://dx.doi.org/10.3390/ijms23020647 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mertowska, Paulina
Mertowski, Sebastian
Smarz-Widelska, Iwona
Grywalska, Ewelina
Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title_full Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title_fullStr Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title_full_unstemmed Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title_short Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases
title_sort biological role, mechanism of action and the importance of interleukins in kidney diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775480/
https://www.ncbi.nlm.nih.gov/pubmed/35054831
http://dx.doi.org/10.3390/ijms23020647
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