Premature Termination Codon in 5′ Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation

Arrhythmogenic cardiomyopathy is a heritable heart disease associated with desmosomal mutations, especially premature termination codon (PTC) variants. It is known that PTC triggers the nonsense-mediated decay (NMD) mechanism. It is also accepted that PTC in the last exon escapes NMD; however, the m...

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Detalles Bibliográficos
Autores principales: Vallverdú-Prats, Marta, Brugada, Ramon, Alcalde, Mireia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775493/
https://www.ncbi.nlm.nih.gov/pubmed/35054841
http://dx.doi.org/10.3390/ijms23020656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775493/
https://www.ncbi.nlm.nih.gov/pubmed/35054841
http://dx.doi.org/10.3390/ijms23020656

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