Cargando…
Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
Adipose tissue dysfunction is strongly associated with obesity and its metabolic complications such as type 2 diabetes and cardiovascular diseases. It is well established that lipid-overloaded adipose tissue produces a large range of secreted molecules that contribute a pro-inflammatory microenviron...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775592/ https://www.ncbi.nlm.nih.gov/pubmed/35054817 http://dx.doi.org/10.3390/ijms23020632 |
_version_ | 1784636623536783360 |
---|---|
author | Lecoutre, Simon Clément, Karine Dugail, Isabelle |
author_facet | Lecoutre, Simon Clément, Karine Dugail, Isabelle |
author_sort | Lecoutre, Simon |
collection | PubMed |
description | Adipose tissue dysfunction is strongly associated with obesity and its metabolic complications such as type 2 diabetes and cardiovascular diseases. It is well established that lipid-overloaded adipose tissue produces a large range of secreted molecules that contribute a pro-inflammatory microenvironment which subsequently disseminates towards multi-organ metabolic homeostasis disruption. Besides physiopathological contribution of adipose-derived molecules, a new paradigm is emerging following the discovery that adipocytes have a propensity to extrude damaged mitochondria in the extracellular space, to be conveyed through the blood and taken up by cell acceptors, in a process called intercellular mitochondria transfer. This review summarizes the discovery of mitochondria transfer, its relation to cell quality control systems and recent data that demonstrate its relevant implication in the context of obesity-related adipose tissue dysfunction. |
format | Online Article Text |
id | pubmed-8775592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87755922022-01-21 Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer Lecoutre, Simon Clément, Karine Dugail, Isabelle Int J Mol Sci Review Adipose tissue dysfunction is strongly associated with obesity and its metabolic complications such as type 2 diabetes and cardiovascular diseases. It is well established that lipid-overloaded adipose tissue produces a large range of secreted molecules that contribute a pro-inflammatory microenvironment which subsequently disseminates towards multi-organ metabolic homeostasis disruption. Besides physiopathological contribution of adipose-derived molecules, a new paradigm is emerging following the discovery that adipocytes have a propensity to extrude damaged mitochondria in the extracellular space, to be conveyed through the blood and taken up by cell acceptors, in a process called intercellular mitochondria transfer. This review summarizes the discovery of mitochondria transfer, its relation to cell quality control systems and recent data that demonstrate its relevant implication in the context of obesity-related adipose tissue dysfunction. MDPI 2022-01-06 /pmc/articles/PMC8775592/ /pubmed/35054817 http://dx.doi.org/10.3390/ijms23020632 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lecoutre, Simon Clément, Karine Dugail, Isabelle Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title | Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title_full | Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title_fullStr | Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title_full_unstemmed | Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title_short | Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer |
title_sort | obesity-related adipose tissue remodeling in the light of extracellular mitochondria transfer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775592/ https://www.ncbi.nlm.nih.gov/pubmed/35054817 http://dx.doi.org/10.3390/ijms23020632 |
work_keys_str_mv | AT lecoutresimon obesityrelatedadiposetissueremodelinginthelightofextracellularmitochondriatransfer AT clementkarine obesityrelatedadiposetissueremodelinginthelightofextracellularmitochondriatransfer AT dugailisabelle obesityrelatedadiposetissueremodelinginthelightofextracellularmitochondriatransfer |