Extended Prophylactic Effect of N-Tert-Butyl-α-Phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta

Antioxidant N-tert-Butyl-α-phenylnitron (PBN) partly protected embryos from the negative effects of a DNA demethylating drug 5-azacytidine during pregnancy. Our aim was to investigate PBN’s impact on the placenta. Fischer rat dams were treated on gestation days (GD) 12 and 13 by PBN (40 mg/kg), foll...

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Detalles Bibliográficos
Autores principales: Sobočan, Nikola, Himelreich-Perić, Marta, Katušić-Bojanac, Ana, Krasić, Jure, Sinčić, Nino, Majić, Željka, Jurić-Lekić, Gordana, Šerman, Ljiljana, Marić, Andreja, Ježek, Davor, Bulić-Jakuš, Floriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775603/
https://www.ncbi.nlm.nih.gov/pubmed/35054786
http://dx.doi.org/10.3390/ijms23020603

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