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Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the impleme...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775644/ https://www.ncbi.nlm.nih.gov/pubmed/35054822 http://dx.doi.org/10.3390/ijms23020636 |
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author | Kilanowska, Agnieszka Ziółkowska, Agnieszka |
author_facet | Kilanowska, Agnieszka Ziółkowska, Agnieszka |
author_sort | Kilanowska, Agnieszka |
collection | PubMed |
description | Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future. |
format | Online Article Text |
id | pubmed-8775644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87756442022-01-21 Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects Kilanowska, Agnieszka Ziółkowska, Agnieszka Int J Mol Sci Review Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future. MDPI 2022-01-07 /pmc/articles/PMC8775644/ /pubmed/35054822 http://dx.doi.org/10.3390/ijms23020636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kilanowska, Agnieszka Ziółkowska, Agnieszka Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title_full | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title_fullStr | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title_full_unstemmed | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title_short | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
title_sort | apoptosis in type 2 diabetes: can it be prevented? hippo pathway prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775644/ https://www.ncbi.nlm.nih.gov/pubmed/35054822 http://dx.doi.org/10.3390/ijms23020636 |
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