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Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study

Background: Existing literature suggests that frequent consumption of sugar-sweetened drinks may be associated with lower semen quality. Studies performed in mice suggest a dose-response relationship between intake of saccharin or aspartame, two artificial sweeteners, and sperm and testis function....

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Autores principales: Meldgaard, Maiken, Brix, Nis, Gaml-Sørensen, Anne, Ernst, Andreas, Ramlau-Hansen, Cecilia Høst, Tøttenborg, Sandra Søgaard, Hougaard, Karin Sørig, Bonde, Jens Peter Ellekilde, Toft, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775653/
https://www.ncbi.nlm.nih.gov/pubmed/35055501
http://dx.doi.org/10.3390/ijerph19020682
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author Meldgaard, Maiken
Brix, Nis
Gaml-Sørensen, Anne
Ernst, Andreas
Ramlau-Hansen, Cecilia Høst
Tøttenborg, Sandra Søgaard
Hougaard, Karin Sørig
Bonde, Jens Peter Ellekilde
Toft, Gunnar
author_facet Meldgaard, Maiken
Brix, Nis
Gaml-Sørensen, Anne
Ernst, Andreas
Ramlau-Hansen, Cecilia Høst
Tøttenborg, Sandra Søgaard
Hougaard, Karin Sørig
Bonde, Jens Peter Ellekilde
Toft, Gunnar
author_sort Meldgaard, Maiken
collection PubMed
description Background: Existing literature suggests that frequent consumption of sugar-sweetened drinks may be associated with lower semen quality. Studies performed in mice suggest a dose-response relationship between intake of saccharin or aspartame, two artificial sweeteners, and sperm and testis function. Methods: A cross-sectional study based on data from The Fetal Programming of Semen Quality (FEPOS) Cohort, including 1047 young men (mean age = 19 years) was performed. Each male participant completed an online questionnaire on health, health behavior and diet, and provided a semen sample. The associations between consumption of sugar-sweetened or artificially sweetened beverages (moderate ≥ 3 days/week; infrequent < 3 days/week) and semen quality were analyzed using a multivariable, negative, binomial regression model. Results: Sugar-sweetened or artificially sweetened beverage consumption was not strongly associated with either semen volume, sperm concentration, total sperm count or total motility in young men. The proportion of morphologically normal sperm was 11% lower (0.89 (95% CI 0.76, 1.04)) for moderate (≥3 days/week) consumption of artificially sweetened beverages relative to infrequent (<3 days/week). Conclusion: Consumption of sugar-sweetened or artificially sweetened beverages, at the levels present in this study had limited effect on the measured markers of semen quality in young men.
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spelling pubmed-87756532022-01-21 Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study Meldgaard, Maiken Brix, Nis Gaml-Sørensen, Anne Ernst, Andreas Ramlau-Hansen, Cecilia Høst Tøttenborg, Sandra Søgaard Hougaard, Karin Sørig Bonde, Jens Peter Ellekilde Toft, Gunnar Int J Environ Res Public Health Article Background: Existing literature suggests that frequent consumption of sugar-sweetened drinks may be associated with lower semen quality. Studies performed in mice suggest a dose-response relationship between intake of saccharin or aspartame, two artificial sweeteners, and sperm and testis function. Methods: A cross-sectional study based on data from The Fetal Programming of Semen Quality (FEPOS) Cohort, including 1047 young men (mean age = 19 years) was performed. Each male participant completed an online questionnaire on health, health behavior and diet, and provided a semen sample. The associations between consumption of sugar-sweetened or artificially sweetened beverages (moderate ≥ 3 days/week; infrequent < 3 days/week) and semen quality were analyzed using a multivariable, negative, binomial regression model. Results: Sugar-sweetened or artificially sweetened beverage consumption was not strongly associated with either semen volume, sperm concentration, total sperm count or total motility in young men. The proportion of morphologically normal sperm was 11% lower (0.89 (95% CI 0.76, 1.04)) for moderate (≥3 days/week) consumption of artificially sweetened beverages relative to infrequent (<3 days/week). Conclusion: Consumption of sugar-sweetened or artificially sweetened beverages, at the levels present in this study had limited effect on the measured markers of semen quality in young men. MDPI 2022-01-07 /pmc/articles/PMC8775653/ /pubmed/35055501 http://dx.doi.org/10.3390/ijerph19020682 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meldgaard, Maiken
Brix, Nis
Gaml-Sørensen, Anne
Ernst, Andreas
Ramlau-Hansen, Cecilia Høst
Tøttenborg, Sandra Søgaard
Hougaard, Karin Sørig
Bonde, Jens Peter Ellekilde
Toft, Gunnar
Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title_full Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title_fullStr Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title_full_unstemmed Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title_short Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study
title_sort consumption of sugar-sweetened or artificially sweetened beverages and semen quality in young men: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775653/
https://www.ncbi.nlm.nih.gov/pubmed/35055501
http://dx.doi.org/10.3390/ijerph19020682
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