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Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study
The current study is focused on the influence of hyperglycemia on weight loss in obese premenopausal women. Specifically, the study evaluated the impact of a six-month individualized low-calorie diet combined with moderate exercise on weight reduction and glucose metabolism in obese women with normo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775667/ https://www.ncbi.nlm.nih.gov/pubmed/35055821 http://dx.doi.org/10.3390/ijerph19021001 |
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author | Zalejska-Fiolka, Jolanta Birková, Anna Wielkoszyński, Tomasz Hubková, Beáta Szlachta, Beata Fiolka, Rafał Błaszczyk, Urszula Kuzan, Aleksandra Gamian, Andrzej Mareková, Mária Toborek, Michał |
author_facet | Zalejska-Fiolka, Jolanta Birková, Anna Wielkoszyński, Tomasz Hubková, Beáta Szlachta, Beata Fiolka, Rafał Błaszczyk, Urszula Kuzan, Aleksandra Gamian, Andrzej Mareková, Mária Toborek, Michał |
author_sort | Zalejska-Fiolka, Jolanta |
collection | PubMed |
description | The current study is focused on the influence of hyperglycemia on weight loss in obese premenopausal women. Specifically, the study evaluated the impact of a six-month individualized low-calorie diet combined with moderate exercise on weight reduction and glucose metabolism in obese women with normoglycemia compared to obese women with moderate hyperglycemia. The results indicated that patients with normoglycemia achieved a successful weight loss, which was connected to a decrease in adipose tissue and reflected by diminished content of visceral fat area (VFA) and percent body fat. In contrast, weight reduction in patients with hyperglycemia was connected not only to the loss of VFA but also to undesired decrease in skeletal muscle mass as well as intracellular and total body water. These unfavorable outcomes were observed despite normalization of glucose metabolism reflected by statistically significant lowering glucose, fructosamine, advanced glycation end-products, and HOMA-IR levels. Overall, the obtained results indicate the importance of the measurement of the carbohydrate profile in obese women and the need for an early introduction of weight reduction strategies before the development of hyperglycemia. |
format | Online Article Text |
id | pubmed-8775667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87756672022-01-21 Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study Zalejska-Fiolka, Jolanta Birková, Anna Wielkoszyński, Tomasz Hubková, Beáta Szlachta, Beata Fiolka, Rafał Błaszczyk, Urszula Kuzan, Aleksandra Gamian, Andrzej Mareková, Mária Toborek, Michał Int J Environ Res Public Health Article The current study is focused on the influence of hyperglycemia on weight loss in obese premenopausal women. Specifically, the study evaluated the impact of a six-month individualized low-calorie diet combined with moderate exercise on weight reduction and glucose metabolism in obese women with normoglycemia compared to obese women with moderate hyperglycemia. The results indicated that patients with normoglycemia achieved a successful weight loss, which was connected to a decrease in adipose tissue and reflected by diminished content of visceral fat area (VFA) and percent body fat. In contrast, weight reduction in patients with hyperglycemia was connected not only to the loss of VFA but also to undesired decrease in skeletal muscle mass as well as intracellular and total body water. These unfavorable outcomes were observed despite normalization of glucose metabolism reflected by statistically significant lowering glucose, fructosamine, advanced glycation end-products, and HOMA-IR levels. Overall, the obtained results indicate the importance of the measurement of the carbohydrate profile in obese women and the need for an early introduction of weight reduction strategies before the development of hyperglycemia. MDPI 2022-01-17 /pmc/articles/PMC8775667/ /pubmed/35055821 http://dx.doi.org/10.3390/ijerph19021001 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zalejska-Fiolka, Jolanta Birková, Anna Wielkoszyński, Tomasz Hubková, Beáta Szlachta, Beata Fiolka, Rafał Błaszczyk, Urszula Kuzan, Aleksandra Gamian, Andrzej Mareková, Mária Toborek, Michał Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title | Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title_full | Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title_fullStr | Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title_full_unstemmed | Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title_short | Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study |
title_sort | loss of skeletal muscle mass and intracellular water as undesired outcomes of weight reduction in obese hyperglycemic women: a short-term longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775667/ https://www.ncbi.nlm.nih.gov/pubmed/35055821 http://dx.doi.org/10.3390/ijerph19021001 |
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