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DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which n...

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Autores principales: Irfan, Jahanzaib, Febrianto, Muhammad Rizki, Sharma, Anju, Rose, Thomas, Mahmudzade, Yasamin, Di Giovanni, Simone, Nagy, Istvan, Torres-Perez, Jose Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775747/
https://www.ncbi.nlm.nih.gov/pubmed/35054943
http://dx.doi.org/10.3390/ijms23020752
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author Irfan, Jahanzaib
Febrianto, Muhammad Rizki
Sharma, Anju
Rose, Thomas
Mahmudzade, Yasamin
Di Giovanni, Simone
Nagy, Istvan
Torres-Perez, Jose Vicente
author_facet Irfan, Jahanzaib
Febrianto, Muhammad Rizki
Sharma, Anju
Rose, Thomas
Mahmudzade, Yasamin
Di Giovanni, Simone
Nagy, Istvan
Torres-Perez, Jose Vicente
author_sort Irfan, Jahanzaib
collection PubMed
description While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain.
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spelling pubmed-87757472022-01-21 DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain Irfan, Jahanzaib Febrianto, Muhammad Rizki Sharma, Anju Rose, Thomas Mahmudzade, Yasamin Di Giovanni, Simone Nagy, Istvan Torres-Perez, Jose Vicente Int J Mol Sci Review While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain. MDPI 2022-01-11 /pmc/articles/PMC8775747/ /pubmed/35054943 http://dx.doi.org/10.3390/ijms23020752 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Irfan, Jahanzaib
Febrianto, Muhammad Rizki
Sharma, Anju
Rose, Thomas
Mahmudzade, Yasamin
Di Giovanni, Simone
Nagy, Istvan
Torres-Perez, Jose Vicente
DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title_full DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title_fullStr DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title_full_unstemmed DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title_short DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain
title_sort dna methylation and non-coding rnas during tissue-injury associated pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775747/
https://www.ncbi.nlm.nih.gov/pubmed/35054943
http://dx.doi.org/10.3390/ijms23020752
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