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Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study

While exposure to pesticides is a known risk factor for neurodegenerative brain diseases, little is known about the influence of environment on glaucoma neuropathy. We aimed to determine whether farmers are at higher risk of developing severe primary open-angle glaucoma (POAG). This retrospective co...

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Autores principales: Grosselin, Mathilde, Bouazzi, Leila, Ferreira de Moura, Thomas, Arndt, Carl, Thorigny, Maxime, Sanchez, Stéphane, Denoyer, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775777/
https://www.ncbi.nlm.nih.gov/pubmed/35055748
http://dx.doi.org/10.3390/ijerph19020926
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author Grosselin, Mathilde
Bouazzi, Leila
Ferreira de Moura, Thomas
Arndt, Carl
Thorigny, Maxime
Sanchez, Stéphane
Denoyer, Alexandre
author_facet Grosselin, Mathilde
Bouazzi, Leila
Ferreira de Moura, Thomas
Arndt, Carl
Thorigny, Maxime
Sanchez, Stéphane
Denoyer, Alexandre
author_sort Grosselin, Mathilde
collection PubMed
description While exposure to pesticides is a known risk factor for neurodegenerative brain diseases, little is known about the influence of environment on glaucoma neuropathy. We aimed to determine whether farmers are at higher risk of developing severe primary open-angle glaucoma (POAG). This retrospective cohort study (tertiary referral center, Reims University Hospital, France) included patients diagnosed with POAG in the last two years. Univariate analysis and adjusted multivariate logistic regression were performed to evaluate the association between agricultural profession and all recorded data. Glaucoma severity (primary outcome) and the number of patients who underwent filtering surgery (secondary outcome) were analyzed. In total, 2065 records were screened, and 772 patients were included (66 in the farmer group and 706 in the nonfarmer group). The risk of severe glaucoma was higher in the farmer group (adjusted odds ratio (aOR) 1.87, p = 0.03). More patients underwent filtering surgery in the farmer group in univariate analysis (p = 0.02) but with no statistical significance after adjustment (p = 0.08). These results suggest pesticide exposure may be a factor accelerating the neurodegeneration in POAG, although a direct link between the agricultural profession and the disease requires further extended studies to be demonstrated.
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spelling pubmed-87757772022-01-21 Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study Grosselin, Mathilde Bouazzi, Leila Ferreira de Moura, Thomas Arndt, Carl Thorigny, Maxime Sanchez, Stéphane Denoyer, Alexandre Int J Environ Res Public Health Article While exposure to pesticides is a known risk factor for neurodegenerative brain diseases, little is known about the influence of environment on glaucoma neuropathy. We aimed to determine whether farmers are at higher risk of developing severe primary open-angle glaucoma (POAG). This retrospective cohort study (tertiary referral center, Reims University Hospital, France) included patients diagnosed with POAG in the last two years. Univariate analysis and adjusted multivariate logistic regression were performed to evaluate the association between agricultural profession and all recorded data. Glaucoma severity (primary outcome) and the number of patients who underwent filtering surgery (secondary outcome) were analyzed. In total, 2065 records were screened, and 772 patients were included (66 in the farmer group and 706 in the nonfarmer group). The risk of severe glaucoma was higher in the farmer group (adjusted odds ratio (aOR) 1.87, p = 0.03). More patients underwent filtering surgery in the farmer group in univariate analysis (p = 0.02) but with no statistical significance after adjustment (p = 0.08). These results suggest pesticide exposure may be a factor accelerating the neurodegeneration in POAG, although a direct link between the agricultural profession and the disease requires further extended studies to be demonstrated. MDPI 2022-01-14 /pmc/articles/PMC8775777/ /pubmed/35055748 http://dx.doi.org/10.3390/ijerph19020926 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grosselin, Mathilde
Bouazzi, Leila
Ferreira de Moura, Thomas
Arndt, Carl
Thorigny, Maxime
Sanchez, Stéphane
Denoyer, Alexandre
Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title_full Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title_fullStr Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title_full_unstemmed Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title_short Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study
title_sort severe primary open-angle glaucoma and agricultural profession: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775777/
https://www.ncbi.nlm.nih.gov/pubmed/35055748
http://dx.doi.org/10.3390/ijerph19020926
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